ArticleWorld journal of microbiology & biotechnology2012
Optimization and scale-up of 2,3-butanediol production by Bacillus amyloliquefaciens B10-127.
Article in World journal of microbiology & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 40 citations in OpenAlex.
- Process optimization for mass production of 2,3-butanediol by Bacillus subtilis CS13.Biotechnology for biofuels · 2021Article
- Production of optically pure 2,3-butanediol from Miscanthus floridulus hydrolysate using engineered Bacillus licheniformis strains.World journal of microbiology & biotechnology · 2018Article
- Effect of oxygen mass transfer rate on the production of 2,3-butanediol from glucose and agro-industrial byproducts byBiotechnology for biofuels · 2018Article
- Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production.Journal of industrial microbiology & biotechnology · 2015Article
- Increasing plasmid-based DNA vaccine construct (16 kb pSVK-HBVA) production inBiotechnology, biotechnological equipment · 2015Article
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6 authors at 1 institution in 1 country.
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Abstract
The effects of culture conditions on 2,3-butanediol (2,3-BD) production and its possible scale-up have been studied. A newly isolated Bacillus amyloliquefaciens B10-127, belonged to GRAS microorganisms and showed a remarkable 2,3-BD producing potency, was used for this experiment. Corn steep liquor, soybean meal and ammonium citrate were found to be the key factors in the fermentation according to the results obtained from the Plackett-Burman experimental design. The optimal concentration range of the three factors was examined by the steepest ascent path, and their optimal concentration were further optimized via response surface methodological approach and determined to be 31.9, 22.0 and 5.58 g/l, respectively. The concentration of the obtained 2,3-BD increased significantly with optimized medium (62.7 g/l) when compared with unoptimized medium (45.7 g/l) and the 2,3-BD productivity was about 2.4-fold (The fermentation time was shorten from 72 to 42 h). To observe scale-up effects, batch fermentation was carried out at various working volumes. At a working volume of 20.0 l, the final 2,3-BD concentration and yield were 61.4 and 0.38 g/g at 36 h with a 2,3-BD productivity of 1.71 g/l h. This result shows similar amount of 2,3-BD obtained in lab-scale fermentation, and it is possible to scale up to larger fermentors without major problems.
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