ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
A novel population of α-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Eppur si muove: the dynamic brain pericyte.Fluids and barriers of the CNS · 2025Review
- Expression of α-smooth muscle actin in the lateral ventricle wall of spontaneous hydrocephalus animals.The Journal of veterinary medical science · 2025Article
- Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development.Scientific reports · 2025Article
- Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Pericytes: jack-of-all-trades in cancer-related inflammation.Frontiers in pharmacology · 2024Review
- The Active Role of Pericytes During Neuroinflammation in the Adult Brain.Cellular and molecular neurobiology · 2023Review
- In Vitro Model for Ischemic Stroke: Functional Analysis of Vascular Smooth Muscle Cells.Cellular and molecular neurobiology · 2022Article
- Review
- Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury.Frontiers in immunology · 2021Review
- Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma.Therapeutic advances in medical oncology · 2020Review
- Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke.Current neuropharmacology · 2017Review
- Microvesicles from brain-extract-treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke.Scientific reports · 2016Article
- Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature.PloS one · 2015Article
- Smooth muscle cell phenotypic switching in stroke.Translational stroke research · 2014Review
- Paradoxical effects of heme arginate on survival of myocutaneous flaps.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Localization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress.Frontiers in neuroanatomy · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a rat model of stroke, the spatio-temporal distribution of α-smooth muscle actin-positive, (αSMA+) cells was investigated in the infarcted hemisphere (ipsilateral) and compared with the contralateral hemisphere. At day 3 postischemia, αSMA+ cells were concentrated in two main loci within the ipsilateral hemisphere (Area A) in the medial corpus callosum and (Area B) midway through the striatum adjacent to the lateral ventricle. By day 7 and further by day 14, fewer αSMA+ cells remained in Areas A and B but a steady increase in the peri-infarct was observed. αSMA+ cells also expressed glial acidic fibrillary protein [GFAP: αSMA+/GFAP+ (29%); αSMA+/GFAP- (71%) phenotypes] and feline leukemia virus C receptor 2 (FLVCR2), but not ED1(microglia) and established markers of pericytes normally located in vascular wall. αSMA+ cells were also located close to the subventricular zones (SVZ) adjacent to Areas A and B. In conclusion, αSMA+ cells have been identified in a spatial and temporal sequence from the SVZ, at intermediate loci and in the vicinity of the peri-infarct. It is hypothesized that novel populations of αSMA+ precursors of pericytes are born on the SVZ, migrate into the peri-infarct region and are incorporated into new vessels of the peri-infarct regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.