ReviewOral diseases2013
Current cell models for bioengineering a salivary gland: a mini-review of emerging technologies.
Review in Oral diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Comparative histological and histochemical analysis of the minor salivary glands in porcine species.Scientific reports · 2026Article
- Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023Review
- Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022Review
- Review
- Building a Functional Salivary Gland for Cell-Based Therapy: More than Secretory Epithelial Acini.Tissue engineering. Part A · 2020Review
- JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2020Article
- Epigenetic Modification as a Regulatory Mechanism for Spatiotemporal Dynamics of ANO1 Expression in Salivary Glands.International journal of molecular sciences · 2019Article
- Review
- JAK Inhibitors and Oxidative Stress Control.Frontiers in immunology · 2019Article
- Salivary gland cell aggregates are derived from self-organization of acinar lineage cells.Archives of oral biology · 2019Article
- Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.International journal of molecular sciences · 2018Review
- Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties.Tissue barriers · 2018Review
- Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function.Biomaterials · 2017Article
- Functional effects of proinflammatory factors present in Sjögren's syndrome salivary microenvironment in an in vitro model of human salivary gland.Scientific reports · 2017Article
- Neurons Self-Organize Around Salivary Epithelial Cells in Novel Co-Culture Model.Journal of stem cell and regenerative biology · 2016Article
- Article
- Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice.Experimental and therapeutic medicine · 2015Article
- Defining periodontal health.BMC oral health · 2015Review
- Saliva-microbe interactions and salivary gland dysfunction.Advances in dental research · 2014Review
- Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.Biomaterials research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oral Diseases (2013) 19, 236-244 Saliva plays a major role in maintaining oral health. Patients afflicted with a decrease in saliva secretion (symptomatically, xerostomia) exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. Despite recent improvements in treating xerostomia (e.g., saliva stimulants, saliva substitutes, and gene therapy), there is a need of more scientific advancements that can be clinically applied toward restoration of compromised salivary gland function. Here we provide a summary of the current salivary cell models that have been used to advance restorative treatments via development of an artificial salivary gland. These models represent initial steps toward clinical and translational research, to facilitate creation of clinically safe salivary glands. Further studies in salivary cell lines and primary cells are necessary to improve survival rates, cell differentiation, and secretory function. Additionally, the characterization of salivary progenitor and stem cell markers are necessary. Although these models are not fully characterized, their improvement may lead to the construction of an artificial salivary gland that is in high demand for improving the quality of life of many patients suffering from salivary secretory dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.