ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2012
Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- The immunomodulatory role of seminal plasma in endometrial receptivity and embryo implantation.American journal of clinical and experimental immunology · 2025Review
- Expression patterns of lncRNA MALAT-1 in SARS-COV-2 infection and its potential effect on disease severity via miR-200c-3p and SIRT1.Biochemistry and biophysics reports · 2023Article
- Pregnancy and Severe ARDS with COVID-19: Epidemiology, Diagnosis, Outcomes and Treatment.Seminars in fetal & neonatal medicine · 2023Review
- Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Review
- Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.Human reproduction (Oxford, England) · 2020Article
- Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.Nature communications · 2019Article
- Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges.Frontiers in immunology · 2019Review
- Regulatory T cells in embryo implantation and the immune response to pregnancy.The Journal of clinical investigation · 2018Review
- The T helper type 17/regulatory T cell paradigm in pregnancy.Immunology · 2016Review
- Natural killer cells and regulatory T cells in early pregnancy loss.The International journal of developmental biology · 2014Review
- Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
problemSemen mediates expansion of CD4(+) regulatory T cells (Treg) in the murine female reproductive tract. The impact of semen on Treg in humans, however, remains unclear. METHOD OF STUDY: Using seminal plasma (SP) from 20 healthy donors, we investigated the impact of human semen on CD4(+) T-cell expression of CD127 and CD49d as well as CD4(+) CD127(low) CD49d(low) Treg proliferation, apoptosis, and intracellular expression of FoxP3, TGF-β1, and IL-10.
resultsSP reduced CD4(+) T-cell expression of CD127 and CD49d and increased the proportion of CD127(low) CD49d(low) Treg. This increase was non-proliferative, mediated in part via the conversion of CD4(+) helper T cells into FoxP3(-) but not FoxP3(+) Treg. Additionally, SP induced an increase in intracellular expression of the immunosuppressive cytokine TGF-β1 by the FoxP3(-) but not FoxP3(+) Treg. SP had no impact on Treg intracellular expression of IL-10.
conclusionHuman seminal plasma fosters the non-proliferative increase in the proportion and immunoregulatory activity of FoxP3(-) Treg.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.