Trial reportJournal of dental research2012
Effect of CPP-ACP paste on dental caries in primary teeth: a randomized trial.
Trial report in Journal of dental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis.Journal of dental research · 2019Pooled it
- Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review.PloS one · 2017Pooled it
- Is there a place for Tooth Mousse in the prevention and treatment of early dental caries? A systematic review.BMC oral health · 2015Pooled it
- Non-surgical treatment of dentin caries in preschool children--systematic review.BMC oral health · 2015Pooled it
- Effects of different remineralization agents on MIH defects: a randomized clinical study.Clinical oral investigations · 2022Trial
- Assessment of the effects of a fluoride dentifrice and GC Tooth Mousse on early caries lesions in primary anterior teeth using quantitative light-induced fluorescence: a randomised clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Trial
- MI Varnish and MI Paste Plus in a caries prevention and remineralization study: a randomized controlled trial.Clinical oral investigations · 2018Trial
- A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish.BioMed research international · 2016Trial
- Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Trial
- Cluster-randomized xylitol toothpaste trial for early childhood caries prevention.Journal of dentistry for children (Chicago, Ill.)Trial
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- Evaluation of enamel remineralization potential and anticariogenic efficacy of polydopamine coated biogenic amorphous calcium phosphate.Clinical oral investigations · 2025Article
- Remineralization of Enamel Using Topical Agents among Patients with Orthodontic Brackets:International journal of clinical pediatric dentistry · 2024Article
- Improving Oral Health with Fluoride-Free Calcium-Phosphate-Based Biomimetic Toothpastes: An Update of the Clinical Evidence.Biomimetics (Basel, Switzerland) · 2023Review
- The composite quality score for the appraisal of prospective controlled clinical therapy trials in systematic reviews and its limits.Frontiers in medicine · 2023Review
- State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management.Caries research · 2019Article
- [Difficulty influence factors of dental caries clinical treatment].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Article
- Effect of CPP/ACP on initial bioadhesion to enamel and dentin in situ.TheScientificWorldJournal · 2014Article
- The Protein Level and Molecular Weight Analysis in Different Children's Toothpaste, which Probably Induced Hypersensitivity.Contemporary clinical dentistryArticle
- Effectiveness of MI Varnish™ and PreviDentInternational journal of clinical pediatric dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
This clinical trial tested the effect of daily application of 10% w/v calcium phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste for 1 yr when added to regular toothbrushing with fluoridated toothpaste to prevent dental caries in pre-school children. High-caries-risk children aged 2½ to 3½ yrs in a suburban area of central Thailand were assigned to receive either CPP-ACP (n = 150) or a placebo control (n = 146) in addition to fluoridated toothpaste. The International Caries Detection and Assessment System (ICDAS) was recorded at baseline, 6 mos, and 1 yr. At 1 yr, a significant increase in mean numbers of enamel and dentin caries lesions, as well as dmfs, was found in both groups (p < 0.001). No significant difference was observed between groups on these 3 outcome measures (p = 0.23, 0.84, and 0.91, respectively). The odds of enamel caries lesion transitions to a state of regression or stability, compared with progression from baseline, was also not different between groups [OR = 1.00, 95% CI (0.86, 1.17)]. This trial found that daily application of 10% w/v CPP-ACP paste on school days for 1 yr, when added to regular toothbrushing with a fluoride toothpaste, had no significant added effect in preventing caries in the primary dentition of these pre-school children (ClinicalTrials.gov number CT01 604109).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.