ArticleThe European journal of neuroscience2012
The role of inhibition in oscillatory wave dynamics in the cortex.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- A deep generative adversarial network capturing complex spiral waves in disinhibited circuits of the cerebral cortex.BMC neuroscience · 2023Article
- Propagating wave activity in a tangential cortical slice.Neuroreport · 2020Article
- The effect of inhibition on the existence of traveling wave solutions for a neural field model of human seizure termination.Journal of computational neuroscience · 2018Article
- Resting State EEG Hemispheric Power Asymmetry in Children with Dyslexia.Frontiers in pediatrics · 2016Article
- Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.