Evidence map›Paper›PMID 22805001›Full record

ArticleInfluenza and other respiratory viruses2012

Epidemiology of influenza A (H1N1)pdm09-associated deaths in the United States, September-October 2009.

Joanna Regan, Ashley Fowlkes, Matthew Biggerstaff, Michael A Jhung, Jacqueline Gindler, Erin Kennedy, Victoria Fields, Lyn Finelli, 2009 Pandemic Influenza A (H1N1) Fatal Case Series Investigation Team

Open access · bronzeAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Joanna ReganNational Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Ashley Fowlkes
Matthew Biggerstaff
Michael A Jhung
Jacqueline Gindler
Erin Kennedy
Victoria Fields
Lyn Finelli
2009 Pandemic Influenza A (H1N1) Fatal Case Series Investigation Team
Centers for Disease Control and Prevention · USApple (Israel) · ILCenter for Global Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrom April to July 2009, the United States experienced a wave of influenza A (H1N1)pdm09 virus (H1N1pdm09) infection. The majority of the deaths during that period occurred in persons <65 years of age with underlying medical conditions.

objectiveTo describe the epidemiology of H1N1pdm09-associated deaths in the US during the fall of 2009.

methodsWe collected demographic, medical history, and cause of death information on a nationally representative, stratified random sample of 323 H1N1pdm09-associated deaths that occurred during September 1-October 31, 2009.

resultsData were available for 302/323 (93%) deaths. Most cases (74%) were 18-64 years of age and had ≥ 1 underlying medical condition (72%). Among cases aged <18 years, 16/43 (37%) had a chronic lung disease, and 15/43 (35%) a neurological disorder; among cases aged ≥ 18 years, 94/254 (37%) had a chronic lung disease and 84/254 (33%) had a metabolic disorder. The median number of days between symptom onset and death was six among children (range, 1-48) and 12 among adults (range, 0-109). Influenza antiviral agents were prescribed for 187/268 (70%) of cases, but only 48/153 (31%) received treatment within 2 days of illness onset.

conclusionsThe characteristics of H1N1pdm09 deaths identified during the fall of 2009 were similar to those occurring April-July 2009. While most cases had conditions that were known to increase the risk for severe outcomes and were recommended to receive antiviral therapy, a minority of cases received antivirals early in the course of illness.

Indexed as

AdolescentAdultAgedAged, 80 and overAntiviral AgentsChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedRisk FactorsAntiviral Agents

Identifiers

PMID22805001
PMCPMC4941714
OpenAlexW1559252735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.