Trial reportTransfusion2013
Red blood cell alloimmunization in sickle cell disease: prevalence in 2010.
Trial report in Transfusion, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Medical and Non-medical Costs of Sickle Cell Disease and Treatments from a US Perspective: A Systematic Review and Landscape Analysis.PharmacoEconomics - open · 2022Pooled it
- Blood transfusions for treating acute chest syndrome in people with sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Blood donation barriers and facilitators of Sub-Saharan African migrants and minorities in Western high-income countries: a systematic review of the literature.Transfusion medicine (Oxford, England) · 2019Pooled it
- Applying molecular immunohaematology to regularly transfused thalassaemic patients in Thailand.Blood transfusion = Trasfusione del sangue · 2014Trial
- Strategies to mitigate transfusion-associated red blood cell alloimmunization in sickle cell disease: A retrospective analysis.Transfusion · 2025Article
- Assessment of erythrocyte alloimmunization among patients treated at a Brazilian university hospital.Hematology, transfusion and cell therapy · 2024Article
- Review
- Article
- Adverse events of red blood cell transfusions in patients with sickle cell disease.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Review
- One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel.Haematologica · 2021Article
- Development and validation of a universal blood donor genotyping platform: a multinational prospective study.Blood advances · 2020Article
- Prevalence and risk factors for red blood cell alloimmunisation among sickle cell patients in Mwanza City, Tanzania.African journal of laboratory medicine · 2020Article
- Barriers and motivators of Ghanaian and African-Surinamese migrants to donate blood.Health & social care in the community · 2019Article
- The supply chain of migrant blood donors: an organisational interview study.Vox sanguinis · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease.Blood advances · 2018Article
- Red blood cell alloimmunization in sickle cell disease: assessment of transfusion protocols during two time periods.Transfusion · 2018Article
- TheJournal of hematology · 2017Article
- Medical and economic implications of strategies to prevent alloimmunization in sickle cell disease.Transfusion · 2017Review
- The Impact of Extended Typing On Red Blood Cell Alloimmunization in Transfused Patients.Open access Macedonian journal of medical sciences · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundTransfusion of red blood cells (RBCs) is frequently required for care of individuals with sickle cell disease (SCD). Alloimmunization rates are high and may be reduced by matching for RBC antigens that can cause alloimmunization. STUDY DESIGN AND
methodsDuring the PROACTIVE Feasibility Study, patients with SCD age 2 years or older admitted for pain without acute chest syndrome were enrolled for possible randomization to preventive blood transfusion or standard care. Transfusion and antibody histories were obtained at each site, and antibody screening was done, to assess transfusion burden and alloimmunization prevalence. Participating sites were surveyed regarding antigen matching practice.
resultsA total of 237 patients (169 SS, 42 SC, 15 Sβ(0) -thalassemia, 11 Sβ(+) -thalassemia), 118 males and 119 females, were enrolled. Mean age was 19.3 years (range, 2.0-68.0); there were 122 children and 115 adults. A total of 75.8% had received at least a single transfusion of RBCs before the study. Thirty-four patients (14.4%) had a history of at least one alloantibody and 17 of these had more than one. When surveyed, 19 sites (83% of responders) reported antigen matching to at least include C, E, and K for transfusion of all patients with SCD.
conclusionThough antigen typing before transfusion of people with SCD and providing antigen-negative units is now widely employed by sickle cell centers, the alloimmunization rate remains quite high in contemporary sickle cell populations and may be due in large part to transfusions received at institutions not providing extended matching.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.