ArticleCurrent molecular medicine2012
HSF1, a versatile factor in tumorogenesis.
Article in Current molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Antitumor Activities of Aqueous Cinnamon Extract on 5637 Cell Line of Bladder Cancer through Glycolytic Pathway.International journal of inflammation · 2022Article
- HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity.Cells · 2020Review
- Molecular Profiling Reveals Common and Specific Development Processes in Different Types of Gynecologic Cancers.Frontiers in oncology · 2020Article
- Regulation of stress signaling pathways by protein lipoxidation.Redox biology · 2019Review
- NRF2 transcriptionally activates theThe Journal of biological chemistry · 2018Article
- Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer.Yonsei medical journal · 2018Article
- Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Mammalian HspB1 (Hsp27) is a molecular sensor linked to the physiology and environment of the cell.Cell stress & chaperones · 2017Review
- Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.Molecular and cellular biology · 2016Article
- Heat Shock Factor 1 Mediates Latent HIV Reactivation.Scientific reports · 2016Article
- Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.Oncogene · 2015Article
- Protecting the normal in order to better kill the cancer.Cancer medicine · 2015Review
- Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.Oncotarget · 2015Article
- HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression.Oncogene · 2015Article
- MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma.Oncotarget · 2015Article
- Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases.Immunity & ageing : I & A · 2015Review
- Heat shock in the springtime.Cell stress & chaperones · 2014Article
- HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins.Cancers · 2014Article
- Molecular cochaperones: tumor growth and cancer treatment.Scientifica · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
HSF1 is an essential factor in the acute response to proteotoxic stress, in which it causes rapid transcription of heat shock protein (HSP) genes in order to permit survival of cells and restoration of global protein quality. In addition to this property however, HSF1 is chronically activated or overexpressed in a wide range of cancers and is essential for multiple pathways of malignant transformation. Studies in recent years indicate a remarkable pleiotropy in the properties of HSF1 in cancer. HSF1 functions as a transcription factor for HSP genes, reminiscent of its role in the stress response, and the resultant elevation in HSP levels leads to a reduction in programmed cell death and senescence and permits overexpression of mutated oncogenic protein clients required to fuel tumor growth. In addition HSF1 plays a role as a signal modulator, stimulating kinase activity, regulating energy metabolism and permitting the development of polyploidy in cancer cells. HSF1 can also function as an inhibitor of transcription and in cooperation with NuRD family factors can repress genes that oppose metastasis. Inhibitors of HSF1 are undergoing selection and future studies may see the testing of HSF1 as a target in cancer therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.