ArticleThe journal of physical chemistry. B2012
Mechanisms of budding of nanoscale particles through lipid bilayers.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mechanical Agitation-Assisted Transmembrane Drug Delivery by Magnetically Powered Spiky Nanorobots.Research (Washington, D.C.) · 2025Article
- Study of impacts of two types of cellular aging on the yeast bud morphogenesis.PLoS computational biology · 2024Article
- Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses.Sub-cellular biochemistry · 2024Review
- Entropy-Mediated Nanoparticle Cellular Uptake.Small science · 2024Article
- The role of size and nature in nanoparticle binding to a model lung membrane: an atomistic study.Nanoscale advances · 2021Article
- Role of combined cell membrane and wall mechanical properties regulated by polarity signals in cell budding.Physical biology · 2020Article
- Probing Nanoparticle/Membrane Interactions by Combining Amphiphilic Diblock Copolymer Assembly and Plasmonics.The journal of physical chemistry. B · 2020Article
- Nanoparticles binding to lipid membranes: from vesicle-based gels to vesicle tubulation and destruction.Nanoscale · 2019Article
- Why Enveloped Viruses Need Cores-The Contribution of a Nucleocapsid Core to Viral Budding.Biophysical journal · 2018Article
- Anchored but not internalized: shape dependent endocytosis of nanodiamond.Scientific reports · 2017Article
- Emerging metrology for high-throughput nanomaterial genotoxicology.Mutagenesis · 2017Review
- Partial wrapping and spontaneous endocytosis of spherical nanoparticles by tensionless lipid membranes.The Journal of chemical physics · 2016Article
- Simulations show that virus assembly and budding are facilitated by membrane microdomains.Biophysical journal · 2015Article
- Membrane properties involved in calcium-stimulated microparticle release from the plasma membranes of S49 lymphoma cells.TheScientificWorldJournal · 2014Article
- Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes.International journal of nanomedicine · 2014Article
- Viral membrane scission.Annual review of cell and developmental biology · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We examine the budding of a nanoscale particle through a lipid bilayer using molecular dynamics simulations, free energy calculations, and an elastic theory, with the aim of determining the extent to which equilibrium elasticity theory can describe the factors that control the mechanism and efficiency of budding. The particle is a smooth sphere which experiences attractive interactions to the lipid head groups. Depending on the parameters, we observe four classes of dynamical trajectories: particle adhesion to the membrane, stalled partially wrapped states, budding followed by scission, and membrane rupture. In most regions of parameter space we find that the elastic theory agrees nearly quantitatively with the simulated phase behavior as a function of adhesion strength, membrane bending rigidity, and particle radius. However, at parameter values near the transition between particle adhesion and budding, we observe long-lived partially wrapped states which are not captured by existing elastic theories. These states could constrain the accessible system parameters for those enveloped viruses or drug delivery vehicles which rely on exo- or endocytosis for membrane transport.
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