SynthesisCanadian journal of gastroenterology = Journal canadien de gastroenterologie2012
A meta-analysis of nutritional supplementation for management of hospitalized alcoholic hepatitis.
Synthesis in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019Guideline
- Corticosteroids Versus Pentoxifylline for Severe Alcoholic Hepatitis: A Sequential Analysis of Randomized Controlled Trials.Journal of clinical gastroenterologyPooled it
- Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease.Journal of cachexia, sarcopenia and muscle · 2025Article
- Redefining Nutritional Requirements in End-Stage Liver Disease: Towards a Personalized Approach.Nutrients · 2023Observational
- Review
- Prospective clinical trials and novel therapies in the medical management of severe alcohol-associated hepatitis.Clinical liver disease · 2022Review
- Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury.Current issues in molecular biology · 2022Review
- An update on the genetics of alcoholic liver disease.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
- Approaching Alcohol Use Disorder After Liver Transplantation for Acute Alcoholic Hepatitis.Clinics in liver disease · 2021Review
- [Medical Treatment of Alcoholic Liver Disease].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Review
- Nutrition in alcohol-related liver disease: Physiopathology and management.World journal of gastroenterology · 2020Review
- EASL Clinical Practice Guidelines on nutrition in chronic liver disease.Journal of hepatology · 2019Review
- Sarcopenia in Alcoholic Liver Disease: Clinical and Molecular Advances.Alcoholism, clinical and experimental research · 2017Review
- Sarcopenia from mechanism to diagnosis and treatment in liver disease.Journal of hepatology · 2016Review
- Nutrition and Alcoholic Liver Disease: Effects of Alcoholism on Nutrition, Effects of Nutrition on Alcoholic Liver Disease, and Nutritional Therapies for Alcoholic Liver Disease.Clinics in liver disease · 2016Review
- Comprehensive risk assessment for early neurologic complications after liver transplantation.World journal of gastroenterology · 2016Article
- Cause and management of muscle wasting in chronic liver disease.Current opinion in gastroenterology · 2016Review
- New treatment options for alcoholic hepatitis.World journal of gastroenterology · 2016Review
- Prognostic models for alcoholic hepatitis.Biomarker research · 2015Article
- Treatment to improve nutrition and functional capacity evaluation in liver transplant candidates.Current treatment options in gastroenterology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlcoholic liver disease (ALD) is associated with a high risk of morbidity and mortality. Malnutrition accompanies this condition and may be both a consequence of and contributor to the pathology. Many trials have investigated the benefits of providing supplemental nutrition in the management of patients with ALD. The present study is a meta-analysis of the available evidence.
methodA meta-analysis of randomized controlled studies comparing nutritional supplementation plus a normal hospital diet versus diet alone.
resultsSeven randomized controlled studies including 262 patients with ALD were identified. Pooled analysis revealed no statistical difference in mortality between groups given special nutritional therapy versus a normal balanced diet (OR 0.80 [95% CI 0.42 to 1.52]). In addition, nutrition did not significantly improve ascites (OR 1.29 [95% CI 0.52 to 3.20]) or any biochemical parameters. However, encephalopathy showed a significant improvement or resolution (OR 0.24 [95% CI 0.06 to 0.93]).
conclusionNutritional supplementation provided no mortality benefit in patients with ALD, and neither ascites nor biochemical parameters significantly improved. However, encephalopathy was significantly ameliorated and, therefore, nutritional supplementation should be encouraged in that setting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.