ArticlePediatric reports2012
Non-invasive ventilation in acute respiratory failure in children.
Article in Pediatric reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Dexmedetomidine for acute respiratory conditions requiring non-invasive respiratory support in pediatric and adult patients: systematic review and meta-analysis of the literature.Frontiers in medicine · 2026Pooled it
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Efficacy of Non-invasive Ventilation Compared to Intubation in Pediatric Acute Respiratory Failure: A Meta-Analysis.Cureus · 2026Review
- Article
- Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study).Critical care (London, England) · 2024Observational
- Outcome of Noninvasive Respiratory Support in Pediatric High-Dependency Units for Acute Respiratory Distress.Respiratory care · 2023Article
- Doing more with less: The use of non-invasive ventilatory support in a resource-limited setting.PloS one · 2023Article
- Development of a deep learning model that predicts Bi-level positive airway pressure failure.Scientific reports · 2022Article
- A multicentered study on efficiency of noninvasive ventilation procedures (SAFE-NIV)Turkish journal of medical sciences · 2021Observational
- Risk Factors for Noninvasive Ventilation Failure in Children Post-Hematopoietic Cell Transplant.Frontiers in oncology · 2021Article
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
- Consideration of the respiratory support strategy of severe acute respiratory failure caused by SARS-CoV-2 infection in children.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Noninvasive Ventilation and Mechanical Insufflator-Exsufflator for Acute Respiratory Failure in Children With Neuromuscular Disorders.Frontiers in pediatrics · 2020Review
- Noninvasive Ventilation and High-Flow NasalSultan Qaboos University medical journal · 2018Review
- Physiological impact of high-flow nasal cannula therapy on postextubation acute respiratory failure after pediatric cardiac surgery: a prospective observational study.Journal of intensive care · 2017Article
- Non-invasive mechanical ventilation after heart surgery in children.BMC pulmonary medicine · 2016Observational
- Effectiveness of flow inflating device in providing Continuous Positive Airway Pressure for critically ill children in limited-resource settings: A prospective observational study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016Article
- High flow on the rise-pediatric perspectives on the FLORALI trial.Journal of thoracic disease · 2015Article
- NIV-Helmet in Severe Hypoxemic Acute Respiratory Failure.Case reports in pediatrics · 2015Article
- What's new on NIV in the PICU: does everyone in respiratory failure require endotracheal intubation?Intensive care medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper is to assess the clinical efficacy of non-invasive ventilation (NIV) in avoiding endotracheal intubation (ETI), to demonstrate clinical and gasometric improvement and to identify predictive risk factors associated with NIV failure. An observational prospective clinical study was carried out. Included Patients with acute respiratory disease (ARD) treated with NIV, from November 2006 to January 2010 in a Pediatric Intensive Care Unit (PICU). NIV was used in 151 patients with acute respiratory failure (ARF). Patients were divided in two groups: NIV success and NIV failure, if ETI was required. Mean age was 7.2±20.3 months (median: 1 min: 0,3 max.: 156). Main diagnoses were bronchiolitis in 102 (67.5%), and pneumonia in 44 (29%) patients. There was a significant improvement in respiratory rate (RR), heart rate (HR), pH, and pCO(2) at 2, 6, 12 and 24 hours after NIV onset (P<0.05) in both groups. Improvement in pulse oximetric saturation/fraction of inspired oxygen (SpO(2)/FiO(2)) was verified at 2, 4, 6, 12 and 24 hours after NIV onset in the success group (P<0.001). In the failure group, significant SpO(2)/FiO(2) improvement was only observed in the first 4 hours. NIV failure occurred in 34 patients (22.5%). Risk factors for NIV failure were apnea, prematurity, pneumonia, and bacterial co-infection (P<0.05). Independent risk factors for NIV failure were apneia (P<0.001; odds ratio 15.8; 95% confidence interval: 3.42-71.4) and pneumonia (P<0.001, odds ratio 31.25; 95% confidence interval: 8.33-111.11). There were no major complications related with NIV. In conclusion this study demonstrates the efficacy of NIV as a form of respiratory support for children and infants with ARF, preventing clinical deterioration and avoiding ETI in most of the patients. Risk factors for failure were related with immaturity and severe infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.