ArticlePloS one2012
Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Article
- Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Developmental emergence of sleep rhythms enables long-term memory inScience advances · 2023Article
- Anti-Mitochondrial and Insecticidal Effects of Artemisinin againstInternational journal of molecular sciences · 2023Article
- Review
- Taste sensing and sugar detection mechanisms ineLife · 2021Article
- Ethanol-guided behavior in Drosophila larvae.Scientific reports · 2021Article
- Impact of alkaloids in food consumption, metabolism and survival in a blood-sucking insect.Scientific reports · 2020Article
- Computational and experimental insights into the chemosensory navigation oProceedings. Biological sciences · 2019Article
- One-trial learning in larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Maggot Instructor: Semi-Automated Analysis of Learning and Memory inFrontiers in psychology · 2018Article
- Aversive and Appetitive Learning inJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Common microbehavioral "footprint" of two distinct classes of conditioned aversion.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Preference for and learning of amino acids in larvalBiology open · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Gustatory processing and taste memory in Drosophila.Journal of neurogenetics · 2016Review
- A Pair of Pharyngeal Gustatory Receptor Neurons Regulates Caffeine-Dependent Ingestion in Drosophila Larvae.Frontiers in cellular neuroscience · 2016Article
- Caffeine Taste Signaling in Drosophila Larvae.Frontiers in cellular neuroscience · 2016Article
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Authors and funding
5 authors.
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Abstract
Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0 mM) than is the case for internal reinforcement (0.6 mM). Interestingly, in previous studies (Niewalda et al. 2008, Schipanski et al 2008) we had found the reverse for sodium chloride and fructose/sucrose, such that dose-effect functions for those tastants were shifted towards lower concentrations for feeding as compared to reinforcement, arguing that the differences in dose-effect function between these behaviours do not reflect artefacts of the types of assay used. The current results regarding quinine thus provide a starting point to investigate how the gustatory system is organized on the cellular and/or molecular level to result in different behavioural tuning curves towards a bitter tastant.
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