ArticlePloS one2012
Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Review
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- Measuring biological age using omics data.Nature reviews. Genetics · 2022Review
- Progeria and Aging-Omics Based Comparative Analysis.Biomedicines · 2022Article
- 4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients.Scientific reports · 2021Article
- Article
- The Diagnostic Significance of Usual Biochemical Parameters in Coronavirus Disease 19 (COVID-19): Albumin to Globulin Ratio and CRP to Albumin Ratio.Frontiers in medicine · 2020Article
- Age-Dependent Changes in the Plasma Proteome of Healthy Adults.The journal of nutrition, health & aging · 2020Article
- Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels.PloS one · 2019Article
- Serum peptidome profiling for the diagnosis of colorectal cancer: discovery and validation in two independent cohorts.Oncotarget · 2017Article
- Biological Age Predictors.EBioMedicine · 2017Review
- Circulating Proteomic Signatures of Chronological Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Traditional Chinese medicine and new concepts of predictive, preventive and personalized medicine in diagnosis and treatment of suboptimal health.The EPMA journal · 2014Article
- Serum peptidome patterns of hepatocellular carcinoma based on magnetic bead separation and mass spectrometry analysis.Diagnostic pathology · 2013Article
- Can proteomics yield insight into aging aorta?Proteomics. Clinical applications · 2013Review
- Suboptimal health: a new health dimension for translational medicine.Clinical and translational medicine · 2012Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
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