ArticlePloS one2012
Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species.PLoS genetics · 2024Article
- Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets.American journal of human genetics · 2023Article
- Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation.Nature genetics · 2019Article
- The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.Epigenetics & chromatin · 2019Article
- Interchromosomal interactions: A genomic love story of kissing chromosomes.The Journal of cell biology · 2019Review
- A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation.Scientific reports · 2017Article
- Article
- Pairing and anti-pairing: a balancing act in the diploid genome.Current opinion in genetics & development · 2016Review
- Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.Cell stem cell · 2015Article
- Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.PLoS genetics · 2014Article
- Random monoallelic expression: regulating gene expression one allele at a time.Trends in genetics : TIG · 2014Review
- Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing.Nature biotechnology · 2013Article
- Condensins and 3D Organization of the Interphase Nucleus.Current genetic medicine reports · 2013Article
- Robust 3D DNA FISH using directly labeled probes.Journal of visualized experiments : JoVE · 2013Article
- Epigenetic layers and players underlying neurodevelopment.Trends in neurosciences · 2013Review
- Chromatin organization and transcriptional regulation.Current opinion in genetics & development · 2013Review
- Imprinted green beards: a little less than kin and more than kind.Biology letters · 2013Article
- Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.PLoS genetics · 2013Article
- Natural breaking of the maternal silence at the mouse and human imprinted Prader-Willi locus: A whisper with functional consequences.Rare diseases (Austin, Tex.) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Although somatic homologous pairing is common in Drosophila it is not generally observed in mammalian cells. However, a number of regions have recently been shown to come into close proximity with their homologous allele, and it has been proposed that pairing might be involved in the establishment or maintenance of monoallelic expression. Here, we investigate the pairing properties of various imprinted and non-imprinted regions in mouse tissues and ES cells. We find by allele-specific 4C-Seq and DNA FISH that the Kcnq1 imprinted region displays frequent pairing but that this is not dependent on monoallelic expression. We demonstrate that pairing involves larger chromosomal regions and that the two chromosome territories come close together. Frequent pairing is not associated with imprinted status or DNA repair, but is influenced by chromosomal location and transcription. We propose that homologous pairing is not exclusive to specialised regions or specific functional events, and speculate that it provides the cell with the opportunity of trans-allelic effects on gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.