ArticlePloS one2012
Transcriptomes reveal genetic signatures underlying physiological variations imposed by different fermentation conditions in Lactobacillus plantarum.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Biodegradation of ethanol and acetaldehyde by Lactiplantibacillus plantarum YDL-01 from healthy human feces.Biodegradation · 2026Article
- Adaptation ofMicroorganisms · 2023Article
- Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota.Biomedicines · 2021Review
- RNA-seq based transcriptional analysis of Saccharomyces cerevisiae and Lachancea thermotolerans in mixed-culture fermentations under anaerobic conditions.BMC genomics · 2019Article
- A metabolomics and proteomics study of the Lactobacillus plantarum in the grass carp fermentation.BMC microbiology · 2018Article
- Constraint-based modeling in microbial food biotechnology.Biochemical Society transactions · 2018Review
- Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness inFrontiers in microbiology · 2018Article
- Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Transcriptional reprogramming and phenotypic switching associated with the adaptation of Lactobacillus plantarum C2 to plant niches.Scientific reports · 2016Article
- Microbial bioinformatics for food safety and production.Briefings in bioinformatics · 2016Review
- Recent Advances in Screening of Anti-Campylobacter Activity in Probiotics for Use in Poultry.Frontiers in microbiology · 2016Review
- Improving healthspan via changes in gut microbiota and fermentation.Age (Dordrecht, Netherlands) · 2015Review
- Identification of Oxygen-Responsive Transcripts in the Silage Inoculant Lactobacillus buchneri CD034 by RNA Sequencing.PloS one · 2015Article
- Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches.Frontiers in microbiology · 2015Review
- Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness.Microbial cell factories · 2014Article
- Transcriptome-based characterization of interactions between Saccharomyces cerevisiae and Lactobacillus delbrueckii subsp. bulgaricus in lactose-grown chemostat cocultures.Applied and environmental microbiology · 2013Article
- Identification of critical genes for growth in olive brine by transposon mutagenesis of Lactobacillus pentosus C11.Applied and environmental microbiology · 2013Article
- Explaining microbial phenotypes on a genomic scale: GWAS for microbes.Briefings in functional genomics · 2013Review
- Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactic acid bacteria (LAB) are utilized widely for the fermentation of foods. In the current post-genomic era, tools have been developed that explore genetic diversity among LAB strains aiming to link these variations to differential phenotypes observed in the strains investigated. However, these genotype-phenotype matching approaches fail to assess the role of conserved genes in the determination of physiological characteristics of cultures by environmental conditions. This manuscript describes a complementary approach in which Lactobacillus plantarum WCFS1 was fermented under a variety of conditions that differ in temperature, pH, as well as NaCl, amino acid, and O(2) levels. Samples derived from these fermentations were analyzed by full-genome transcriptomics, paralleled by the assessment of physiological characteristics, e.g., maximum growth rate, yield, and organic acid profiles. A data-storage and -mining suite designated FermDB was constructed and exploited to identify correlations between fermentation conditions and industrially relevant physiological characteristics of L. plantarum, as well as the associated transcriptome signatures. Finally, integration of the specific fermentation variables with the transcriptomes enabled the reconstruction of the gene-regulatory networks involved. The fermentation-genomics platform presented here is a valuable complementary approach to earlier described genotype-phenotype matching strategies which allows the identification of transcriptome signatures underlying physiological variations imposed by different fermentation conditions.
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