ArticleThe open orthopaedics journal2012
Safety of intra-articular use of atelocollagen for enhanced tissue repair.
Article in The open orthopaedics journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Type I Atelocollagen Interposition Within the ACL Graft During ACL Reconstruction: An Exploratory Clinical and MRI-Based Study.Medicina (Kaunas, Lithuania) · 2026Article
- Ultrasound-Guided Atelocollagen Injection for Chronic Pain After Spinal Surgery: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Bridge enhanced ACL repair vs. ACL reconstruction for ACL tears: A systematic review and meta-analysis of comparative studies.SICOT-J · 2023Article
- Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2021Article
- Healing of partial tear of the supraspinatus tendon after atelocollagen injection confirmed by MRI: A case report.Medicine · 2020Article
- Resolution of Pain and Predictors of Postoperative Opioid use after Bridge-Enhanced Anterior Cruciate Ligament Repair and Anterior Cruciate Ligament Reconstruction.Arthroscopy, sports medicine, and rehabilitation · 2020Article
- Does Atelocollagen Actually Help the Rotator Cuff Healing and Pain Control?Clinics in shoulder and elbow · 2019Article
- Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study.Orthopaedic journal of sports medicine · 2019Article
- The non-reconstructive treatment of complete ACL tear with biological enhancement in clinical and preclinical studies: A systematic review.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2018Review
- The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study.Orthopaedic journal of sports medicine · 2016Article
- Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Collagen is an important biomaterial in intra-articular tissue engineering, but there are unanswered questions about its safety. We hypothesize that the addition of type-I-collagen for primary repair of the Anterior Cruciate Ligament (ACL) might result in a local and systemic reaction in a porcine model after 15 weeks as demonstrated by joint effusion, synovial thickening, elevated intraarticular and systemic leukocyte counts. Further, this reaction might be aggravated by the addition of a platelet concentrate. Eighteen porcine ACLs were transected and repaired with either sutures (n=6), a collagen sponge (n=6), or a collagen-platelet-composite (CPC; n=6). Twelve intact contralateral knees served as controls (n=12). No significant synovial thickening or joint effusion was seen in the collagen-treated knees. Synovial fluid leukocyte counts showed no significant differences between surgically treated and intact knees, and no differences were seen in leukocyte counts of the peripheral blood. The addition of a platelet concentrate to the knee joint resulted in lower serum levels of IL-1β, but serum levels of TNF-α were not significantly different between groups. In conclusion, the presence of collagen, with or without added platelets, did not increase the local or systemic inflammatory reactions following surgery, suggesting that Type I collagen is safe to use in the knee joint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.