ArticleF1000 biology reports2012
Crosstalk between metabolic and neuropsychiatric disorders.
Article in F1000 biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Chamomile Modulates Glucose Metabolism and Neuro-inflammation to Alleviate Stress-Induced Depression in Mice.Molecular neurobiology · 2025Article
- Linking glucose swings and mental health to cardiovascular outcomes and mortality in general practice.Scientific reports · 2025Article
- Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View.International journal of molecular sciences · 2024Article
- Article
- Association between cognitive capacity and metabolic indices in patients with neuropsychiatric disorders.Journal of education and health promotion · 2023Article
- The Effects of Use of Long-Term Second-Generation Antipsychotics on Liver and Kidney Function: A Prospective Study.Diseases (Basel, Switzerland) · 2022Article
- Maternal overnutrition during critical developmental periods leads to different health adversities in the offspring: relevance of obesity, addiction and schizophrenia.Scientific reports · 2019Article
- NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward.Molecular psychiatry · 2019Article
- Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side Effects.Current neuropharmacology · 2018Review
- Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression.Frontiers in neuroscience · 2018Review
- Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice.International journal of immunopathology and pharmacology · 2017Article
- Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.Molecular neuropsychiatry · 2016Article
- Moieties in antidiabetic drugs as a target of insulin receptors in association with common neurological disorders.Biomedical reports · 2016Article
- Emerging from the bottleneck: benefits of the comparative approach to modern neuroscience.Trends in neurosciences · 2015Review
- A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease.Computational and structural biotechnology journal · 2015Review
- Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases.Frontiers in microbiology · 2015Review
- Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship?Neuromolecular medicine · 2014Review
- Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism.Molecular psychiatry · 2014Review
- Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder.Dialogues in clinical neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence supporting the concurrence of metabolic disturbances (e.g. insulin resistance, diabetes and obesity) and neuropsychiatric disorders has been demonstrated in both human and animal studies, suggesting the possibility that they have shared pathophysiological mechanisms. During the past decade, our understanding for the role of insulin in both normal and abnormal central nervous system (CNS) processes has become increasingly refined. Evidence indicates that insulin is a pleiotropic peptide, critical to neurotrophism, neuroplasticity, and neuromodulation. Moreover, the role of insulin underscores its importance in the development of several neuropsychiatric disorders, including, but not limited to, mechanisms involved in the pathogenesis and progression towards diabetes, obesity, and neurodegenerative disorders, such as Alzheimer's disease. This review focuses on the insulin-mediated effects on normal and abnormal brain function and discusses why targeting insulin-related pathways in the brain may emerge as a new approach for refining treatment of neurological and psychiatric disorders.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.