ReviewPLoS medicine2012
HIV treatment as prevention: the utility and limitations of ecological observation.
Review in PLoS medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Trial
- Can combination prevention strategies reduce HIV transmission in generalized epidemic settings in Africa? The HPTN 071 (PopART) study plan in South Africa and Zambia.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- On characterizing gender and locational composition of adult PLHIV in Nigeria: Implications for HIV programming.PLOS global public health · 2024Article
- Population uptake and effectiveness of test-and-treat antiretroviral therapy guidelines for preventing the global spread of HIV: an ecological cross-national analysis.HIV medicine · 2019Article
- Client and Provider Perspectives on Antiretroviral Treatment Uptake and Adherence Among People Who Inject Drugs in Indonesia, Ukraine and Vietnam: HPTN 074.AIDS and behavior · 2019Article
- The relationship between gastrointestinal symptom attribution, bothersomeness, and antiretroviral adherence among adults with HIV.AIDS care · 2018Article
- High HIV-1 RNA Among Newly Diagnosed People in Botswana.AIDS research and human retroviruses · 2018Article
- Reduction in HIV community viral loads following the implementation of a "Treatment as Prevention" strategy over 2 years at a population-level among men who have sex with men in Hangzhou, China.BMC infectious diseases · 2018Article
- A primer on multiscale modelling of infectious disease systems.Infectious Disease Modelling · 2018Article
- HIV Prevention Efforts and Incidence of HIV in Uganda.The New England journal of medicine · 2017Article
- HIV treatment as prevention among people who inject drugs - a re-evaluation of the evidence.International journal of epidemiology · 2017Article
- The HIV care cascade: Japanese perspectives.PloS one · 2017Article
- Article
- Engagement in the HIV Care Continuum among Key Populations in Tijuana, Mexico.AIDS and behavior · 2016Article
- HIV treatment as prevention in men who have sex with men: examining the evidence.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Review
- Spirituality/Religiosity: A Cultural and Psychological Resource among Sub-Saharan African Migrant Women with HIV/AIDS in Belgium.PloS one · 2016Article
- Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data.Epidemiology (Cambridge, Mass.) · 2015Article
- Modeling infectious disease dynamics in the complex landscape of global health.Science (New York, N.Y.) · 2015Review
- Advances in HIV prevention for serodiscordant couples.Current HIV/AIDS reports · 2014Review
- Use of antiretroviral therapy in households and risk of HIV acquisition in rural KwaZulu-Natal, South Africa, 2004–12: a prospective cohort study.The Lancet. Global health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Results from several observational studies of HIV-discordant couples and a randomized controlled trial (HIV Prevention Trials Network 052) show that antiretroviral therapy (ART) can greatly reduce heterosexual HIV transmission in stable HIV-discordant couples. However, such data do not prove that ART will reduce HIV incidence at the population level. Observational investigations using ecological measures have been used to support the implementation of HIV treatment for the specific purpose of preventing transmission at the population level. Many of these studies note ecological associations between measures of increased ART uptake and decreased HIV transmission. Given the urgency of implementing HIV prevention measures, ecological studies must de facto be used to inform current strategies. However, the hypothesis that widespread ART can eliminate HIV infection may have raised expectations beyond what we may be able to achieve. Here we review and discuss the construct of the exposure and outcome measures and analysis methods used in ecological studies. By examining the strengths and weaknesses of ecological analyses, we aim to aid understanding of the findings from these studies to inform future policy decisions regarding the use of ART for HIV prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.