ArticlePLoS medicine2012
HIV treatment as prevention: principles of good HIV epidemiology modelling for public health decision-making in all modes of prevention and evaluation.
Article in PLoS medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Use of Mathematical Models of Chlamydia Transmission to Address Public Health Policy Questions: A Systematic Review.Sexually transmitted diseases · 2017Pooled it
- The HIV Modes of Transmission model: a systematic review of its findings and adherence to guidelines.Journal of the International AIDS Society · 2014Pooled it
- Surveying the Literature on Implementation Determinants and Strategies for HIV Structural Interventions: A Systematic Review Protocol.medRxiv : the preprint server for health sciences · 2025Article
- Investigating the impact of stochasticity on HIV infection dynamics in CD4Scientific reports · 2024Article
- Evaluation of the use of modelling in resource allocation decisions for HIV and TB.BMJ global health · 2024Article
- Article
- Treatment as prevention for hepatitis C virus in the Middle East and North Africa: a modeling study.Frontiers in public health · 2023Article
- Cost-effectiveness of the HepCATT intervention in specialist drug clinics to improve case-finding and engagement with HCV treatment for people who inject drugs in England.Addiction (Abingdon, England) · 2020Article
- Treatment as prevention for hepatitis C virus in Pakistan: mathematical modelling projections.BMJ open · 2019Article
- Developing a dynamic HIV transmission model for 6 U.S. cities: An evidence synthesis.PloS one · 2019Article
- Insight into treatment of HIV infection from viral dynamics models.Immunological reviews · 2018Review
- Modelling the human immunodeficiency virus (HIV) epidemic: A review of the substance and role of models in South Africa.Southern African journal of HIV medicine · 2018Article
- A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model.Epidemiology (Cambridge, Mass.) · 2016Article
- PrEP Implementation Science: State-of-the-Art and Research Agenda.Journal of the International AIDS Society · 2015Article
- Seasonal PrEP for partners of migrant miners in southern Mozambique: a highly focused PrEP intervention.Journal of the International AIDS Society · 2015Article
- Toward an endgame: finding and engaging people unaware of their HIV-1 infection in treatment and prevention.AIDS research and human retroviruses · 2014Review
- HIV treatment as prevention: contradictory perspectives from dynamic mathematical models.TheScientificWorldJournal · 2014Review
- Future of phylogeny in HIV prevention.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Test-and-treat in Los Angeles: a mathematical model of the effects of test-and-treat for the population of men who have sex with men in Los Angeles County.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions.AIDS (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Public health responses to HIV epidemics have long relied on epidemiological modelling analyses to help prospectively project and retrospectively estimate the impact, cost-effectiveness, affordability, and investment returns of interventions, and to help plan the design of evaluations. But translating model output into policy decisions and implementation on the ground is challenged by the differences in background and expectations of modellers and decision-makers. As part of the PLoS Medicine Collection "Investigating the Impact of Treatment on New HIV Infections"--which focuses on the contribution of modelling to current issues in HIV prevention--we present here principles of "best practice" for the construction, reporting, and interpretation of HIV epidemiological models for public health decision-making on all aspects of HIV. Aimed at both those who conduct modelling research and those who use modelling results, we hope that the principles described here will become a shared resource that facilitates constructive discussions about the policy implications that emerge from HIV epidemiology modelling results, and that promotes joint understanding between modellers and decision-makers about when modelling is useful as a tool in quantifying HIV epidemiological outcomes and improving prevention programming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.