ArticleProceedings of the National Academy of Sciences of the United States of America2012
Mn(II) oxidation by an ascomycete fungus is linked to superoxide production during asexual reproduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 250 citations in OpenAlex.
- Multi-omic landscape of Mn(Ⅱ) oxidation in Achromobacter pulmonis ss21: from multicopper oxidase to metabolic support electron transfer.World journal of microbiology & biotechnology · 2026Article
- Synergy between reactive manganese species and enzymes drives litter decomposition hotspots.Nature communications · 2026Article
- Manganese(II)-oxidizing Ascomycete fungi experience growth benefit on polyphenolic substrate.FEMS microbiology ecology · 2026Article
- Invasive ambrosia beetles have zinc-enriched mandibles: support for the metal-prioritization hypothesis and insights into the mechanisms of metal deposition.Scientific reports · 2026Article
- Microbial responses under sunlight-dark conditions accelerate sequestration and transformation of soil biogenic, redox and non-redox components, including As and Hg.Scientific reports · 2025Article
- Critical Metal Adsorption by Biotic and Abiotic Hydrous Manganese Oxides: Implications for Acid Mine Drainage Resource Recovery.ACS omega · 2025Article
- Root Exudates Mediate the Production of Reactive Oxygen Species in Rhizosphere Soil: Formation Mechanisms and Ecological Effects.Plants (Basel, Switzerland) · 2025Review
- Population-level control of two manganese oxidases expands the niche for bacterial manganese biomineralization.NPJ biofilms and microbiomes · 2025Article
- Article
- Does manganese influence grass litter decomposition on a Hawaiian rainfall gradient?Oecologia · 2024Article
- Isolation, characterization, and genetic manipulation of cold-tolerant, manganese-oxidizingApplied and environmental microbiology · 2024Article
- Understanding the role of manganese oxides in retaining harmful metals: Insights into oxidation and adsorption mechanisms at microstructure level.Eco-Environment & Health · 2024Review
- Mineral-mediated stability of organic carbon in soil and relevant interaction mechanisms.Eco-Environment & Health · 2024Review
- Formation of Biogenic Manganese Oxide Nodules on Hyphae of a New Fungal Isolate of Periconia That Immobilizes Aqueous Copper.Microbes and environments · 2024Article
- Involvement of Bacterial and Fungal Extracellular Products in Transformation of Manganese-Bearing Minerals and Its Environmental Impact.International journal of molecular sciences · 2023Review
- Manganese removal and product characteristics of a marine manganese-oxidizing bacterium Bacillus sp. FF-1.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- A critical review of mineral-microbe interaction and co-evolution: mechanisms and applications.National science review · 2022Review
- Carbon Metabolism of a Soilborne Mn(II)-OxidizingInternational journal of molecular sciences · 2022Article
- A new strain of Volutella citrinella with nematode predation and nematicidal activity, isolated from the cysts of potato cyst nematodes in China.BMC microbiology · 2021Article
- Cryptic metabolisms in anoxic subseafloor sediment.Environmental microbiology reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese (Mn) oxides are among the most reactive minerals within the environment, where they control the bioavailability of carbon, nutrients, and numerous metals. Although the ability of microorganisms to oxidize Mn(II) to Mn(III/IV) oxides is scattered throughout the bacterial and fungal domains of life, the mechanism and physiological basis for Mn(II) oxidation remains an enigma. Here, we use a combination of compound-specific chemical assays, microspectroscopy, and electron microscopy to show that a common Ascomycete filamentous fungus, Stilbella aciculosa, oxidizes Mn(II) to Mn oxides by producing extracellular superoxide during cell differentiation. The reactive Mn oxide phase birnessite and the reactive oxygen species superoxide and hydrogen peroxide are colocalized at the base of asexual reproductive structures. Mn oxide formation is not observed in the presence of superoxide scavengers (e.g., Cu) and inhibitors of NADPH oxidases (e.g., diphenylene iodonium chloride), enzymes responsible for superoxide production and cell differentiation in fungi. Considering the recent identification of Mn(II) oxidation by NADH oxidase-based superoxide production by a common marine bacterium (Roseobacter sp.), these results introduce a surprising homology between some prokaryotic and eukaryotic organisms in the mechanisms responsible for Mn(II) oxidation, where oxidation appears to be a side reaction of extracellular superoxide production. Given the versatility of superoxide as a redox reactant and the widespread ability of fungi to produce superoxide, this microbial extracellular superoxide production may play a central role in the cycling and bioavailability of metals (e.g., Hg, Fe, Mn) and carbon in natural systems.
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