ArticleProceedings of the National Academy of Sciences of the United States of America2012
Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serotonin has early, cilia-independent roles in Xenopus left-right patterning.Disease models & mechanisms · 2013Pooled it
- The universe is asymmetric, the mouse brain too.Molecular psychiatry · 2025Article
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- Exome-wide analysis implicates rare protein-altering variants in human handedness.Nature communications · 2024Article
- A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.Molecular biology and evolution · 2023Article
- Nodal asymmetry and hedgehog signaling during vertebrate left-right symmetry breaking.Frontiers in cell and developmental biology · 2022Article
- Theories, laws, and models in evo-devo.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Unveiling the morphogenetic code: A new path at the intersection of physical energies and chemical signaling.World journal of stem cells · 2021Review
- The genetic architecture of structural left-right asymmetry of the human brain.Nature human behaviour · 2021Article
- Review
- Epithelial Cell Chirality Revealed by Three-Dimensional Spontaneous Rotation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form.Developmental biology · 2018Review
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner.Biology open · 2017Article
- From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Cell chirality: emergence of asymmetry from cell culture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Introduction to provocative questions in left-right asymmetry.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Stochastic left-right neuronal asymmetry in Caenorhabditis elegans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
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7 authors.
Funding
Abstract
Many types of embryos' bodyplans exhibit consistently oriented laterality of the heart, viscera, and brain. Errors of left-right patterning present an important class of human birth defects, and considerable controversy exists about the nature and evolutionary conservation of the molecular mechanisms that allow embryos to reliably orient the left-right axis. Here we show that the same mutations in the cytoskeletal protein tubulin that alter asymmetry in plants also affect very early steps of left-right patterning in nematode and frog embryos, as well as chirality of human cells in culture. In the frog embryo, tubulin α and tubulin γ-associated proteins are required for the differential distribution of maternal proteins to the left or right blastomere at the first cell division. Our data reveal a remarkable molecular conservation of mechanisms initiating left-right asymmetry. The origin of laterality is cytoplasmic, ancient, and highly conserved across kingdoms, a fundamental feature of the cytoskeleton that underlies chirality in cells and multicellular organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.