ArticleProceedings of the National Academy of Sciences of the United States of America2012
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed.
- A Cis-Regulatory Duplication in a Hox Hotspot Implicated in Mimetic Convergence in the Bumble Bee Bombus flavifrons.Molecular ecology · 2026Article
- Ectopic Wnt6 expression induces twin-spot markings in the epidermis of the silkworm Bombyx mori - Potential molecular target to discover evolutionary mechanisms of adaptive body coloration in insects.The FEBS journal · 2026Article
- Evolutionary genomic basis of mimicry diversity of Epicopeiidae moths.Molecular biology and evolution · 2026Article
- Cis-regulatory evolution of Wnt family genes contributes to a morphological difference between silkworm species.PLoS biology · 2026Article
- TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026Article
- Evolutionary Divergence of mTOR-mediated Transcriptional Regulation BetweenbioRxiv : the preprint server for biology · 2026Article
- The genetics and evolution of moth melanism in the absence of strong natural selection.National science review · 2026Article
- WntA expression and wing transcriptomics illuminate the evolution of stripe patterns in skipper butterflies.Biology open · 2025Article
- Cis-regulatory evolution ofbioRxiv : the preprint server for biology · 2025Article
- A Notch signal required for a morphological novelty inScience advances · 2025Article
- Hierarchical architecture of neo-sex chromosomes and accelerated adaptive evolution in tortricid moths.Genome research · 2025Article
- A microRNA is the effector gene of a classic evolutionary hotspot locus.Science (New York, N.Y.) · 2024Article
- Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Article
- A micro-RNA is the effector gene of a classic evolutionary hotspot locus.bioRxiv : the preprint server for biology · 2024Article
- Adaptive introgression of a visual preference gene.Science (New York, N.Y.) · 2024Article
- Genetics and the Evolution of Prezygotic Isolation.Cold Spring Harbor perspectives in biology · 2024Review
- Genetic Modification of a Hox Locus Drives Mimetic Color Pattern Variation in a Highly Polymorphic Bumble Bee.Molecular biology and evolution · 2023Article
- Demographically explicit scans for barriers to gene flow using gIMble.PLoS genetics · 2023Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
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Abstract
Although animals display a rich variety of shapes and patterns, the genetic changes that explain how complex forms arise are still unclear. Here we take advantage of the extensive diversity of Heliconius butterflies to identify a gene that causes adaptive variation of black wing patterns within and between species. Linkage mapping in two species groups, gene-expression analysis in seven species, and pharmacological treatments all indicate that cis-regulatory evolution of the WntA ligand underpins discrete changes in color pattern features across the Heliconius genus. These results illustrate how the direct modulation of morphogen sources can generate a wide array of unique morphologies, thus providing a link between natural genetic variation, pattern formation, and adaptation.
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