ArticleProceedings of the National Academy of Sciences of the United States of America2012
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Basal release of 6-cyanodopamine from rabbit isolated aorta and its modulation of vascular reactivity.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- In silico and in vitro investigations of novel Siglec-1 inhibitors in a microglial cell model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Association of the endosomal sorting processes cargo selection and membrane tubulation with human reward system reactivity.European archives of psychiatry and clinical neuroscience · 2026Article
- Lipid Polarization during Cytokinesis.Cells · 2022Review
- Adrenergic α2 receptors are implicated in seizure-induced respiratory arrest in DBA/1 mice.Life sciences · 2021Article
- Membrane and organelle dynamics during cell division.Nature reviews. Molecular cell biology · 2020Review
- Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.Frontiers in pharmacology · 2020Review
- Prazosin induced lysosomal tubulation interferes with cytokinesis and the endocytic sorting of the tumour antigen CD98hc.Biochimica et biophysica acta. Molecular cell research · 2018Article
- Dopamine Receptor Subtypes Differentially Regulate Autophagy.International journal of molecular sciences · 2018Article
- Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle.Oncotarget · 2016Article
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- The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P.Toxicology · 2015Article
- The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.PloS one · 2015Article
- A Catalog of Proteins Expressed in the AG Secreted Fluid during the Mature Phase of the Chinese Mitten Crabs (Eriocheir sinensis).PloS one · 2015Article
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- Non-traditional roles of G protein-coupled receptors in basic cell biology.Molecular bioSystems · 2013Review
- The why and how of phenotypic small-molecule screens.Nature chemical biology · 2013Article
- G protein-coupled receptors participate in cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
Macromolecules enter cells by endocytosis and are sorted to different cellular destinations in early/sorting endosomes. The mechanism and regulation of sorting are poorly understood, although transitions between vesicular and tubular endosomes are important. We found that the antihypertensive drug Prazosin inhibits endocytic sorting by an off-target perturbation of the G protein-coupled receptor dopamine receptor D(3) (DRD3). Prazosin is also a potent cytokinesis inhibitor, likely as a consequence of its effects on endosomes. Prazosin stabilizes a normally transient interaction between DRD3 and the coatomer COPI, a complex involved in membrane transport, and shifts endosomal morphology entirely to tubules, disrupting cargo sorting. RNAi depletion of DRD3 alone also inhibits endocytic sorting, indicating a noncanonical role for a G protein-coupled receptor. Prazosin is a powerful tool for rapid and reversible perturbation of endocytic dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.