ArticleThe Journal of infectious diseases2012
Polyomavirus JC urinary shedding in kidney and liver transplant recipients associated with reduced creatinine clearance.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Longitudinal study of human polyomaviruses viruria in kidney transplant recipients.Clinical and experimental medicine · 2024Article
- Metagenomic Virome Sequencing in Living Donor and Recipient Kidney Transplant Pairs Revealed JC Polyomavirus Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- A globally applicable PCR-based detection and discrimination of BK and JC polyomaviruses.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection.World journal of transplantation · 2016Review
- The association between polyomavirus BK strains and BKV viruria in liver transplant recipients.Scientific reports · 2016Article
- BK polyoma virus infection and renal disease in non-renal solid organ transplantation.Clinical kidney journal · 2016Review
- Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T Cell-depleted peripheral blood and cord blood stem cell transplantations.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014Article
- A review on JC virus infection in kidney transplant recipients.Clinical & developmental immunology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPolyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients.
methodsWe examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relationship to creatinine clearance (CrCl) in a longitudinal study of 41 kidney and 33 liver transplant recipients.
resultsAny polyomavirus urinary shedding was more frequent in liver than kidney recipients (64% vs 39%; P= .03). JCV was excreted more frequently by liver than kidney recipients (71% vs 38%), whereas BKV was shed more often by kidney than liver patients (69% vs 52%). Mean JCV loads were significantly higher than those of BKV in both patient groups (P< .0001). Lower mean CrCl values were significantly associated with JCV shedding in both kidney and liver recipients (P< .001).
conclusionsThese findings suggest that BKV and JCV display different patterns of reactivation and shedding in kidney and liver transplant patients and that JCV may have a role in renal dysfunction in some solid organ transplant recipients.
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Registered trials
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