ArticleInfection and immunity2012
Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 94 citations in OpenAlex.
- Targeting the stringent response alters gene expression and extracellular vesicle RNA inMicrobiology spectrum · 2026Article
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- Staphylococcal lipoproteins and peptidoglycans synergize to drive skin abscess formation.mBio · 2026Article
- Effect of quorum quenching enzyme YtnP on immune response and intestinal microbiota inFrontiers in microbiology · 2026Article
- Murine model of antibiotic-associated Staphylococcus aureus gastrointestinal infections (SAGII) and colonization.Gut pathogens · 2025Article
- Deciphering the function of Com_YlbF domain-containing proteins inJournal of bacteriology · 2025Article
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- WEIGHT LOSS-INDUCED ADIPOSE MACROPHAGE MEMORY CORRESPONDS WITH LOWER ADIPOSE BACTERIAL BURDEN IN MURINE SYSTEMIC STAPHYLOCOCCUS AUREUS INFECTION.Shock (Augusta, Ga.) · 2025Article
- Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025Article
- Altered genomic methylation promotes Staphylococcus aureus persistence in hospital environment.Nature communications · 2024Article
- Evaluation of LPRDA Pentapeptide for the Prevention and Treatment ofInternational journal of molecular sciences · 2024Article
- Exploring the potential of isorhapontigenin: attenuatingmSphere · 2024Article
- The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections.Inflammation and regeneration · 2024Review
- Characteristics ofMicrobiology spectrum · 2024Article
- Catheter-associated Mycobacterium intracellulare biofilm infection in C3HeB/FeJ mice.Scientific reports · 2023Article
- Machine Learning with Alpha Toxin Phenotype to Predict Clinical Outcome in Patients withToxins · 2023Article
- Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis.Antimicrobial agents and chemotherapy · 2023Article
- Bavachin Suppresses Alpha-Hemolysin Expression and Protects Mice from Pneumonia Infection byJournal of microbiology and biotechnology · 2022Article
- Fracture-related infection.Nature reviews. Disease primers · 2022Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is a frequent cause of skin infection and sepsis in humans. Preclinical vaccine studies with S. aureus have used a mouse model with intraperitoneal challenge and survival determination as a measure for efficacy. To appreciate the selection of protective antigens in this model, we sought to characterize the pathological attributes of S. aureus infection in the peritoneal cavity. Testing C57BL/6J and BALB/c mice, >10(9) CFU of S. aureus Newman were needed to produce a lethal outcome in 90% of animals infected via intraperitoneal injection. Both necropsy and histopathology revealed the presence of intraperitoneal abscesses in the vicinity of inoculation sites. Abscesses were comprised of fibrin as well as collagen deposits and immune cells with staphylococci replicating at the center of these lesions. Animals that succumbed to challenge harbored staphylococci in abscess lesions and in blood. The establishment of lethal infections, but not the development of intraperitoneal abscesses, was dependent on S. aureus expression of alpha-hemolysin (Hla). Active immunization with nontoxigenic Hla(H35L) or passive immunization with neutralizing monoclonal antibodies protected mice against early lethal events associated with intraperitoneal S. aureus infection but did not affect the establishment of abscess lesions. These results characterize a mouse model for the study of intraperitoneal abscess formation by S. aureus, a disease that occurs frequently in humans undergoing continuous ambulatory peritoneal dialysis for end-stage renal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.