ReviewCurrent rheumatology reports2012
Lipid paradox in rheumatoid arthritis: changes with rheumatoid arthritis therapies.
Review in Current rheumatology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06724952 (Clinical Study Evaluating Anti Rheumatic Activity and The Role of Silymarin in Attenuating Methotrexate Toxicity in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study Evaluating Anti Rheumatic Activity and The Role of Silymarin in Attenuating Methotrexate Toxicity in Patients With Rheumatoid Arthritis
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Improvements in High-Density Lipoprotein Quantity and Quality Contribute to the Cardiovascular Benefits by Anti-tumor Necrosis Factor Therapies in Rheumatoid Arthritis: A Systemic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Pooled it
- Metabolic and systemic inflammation status in rheumatoid arthritis-fasting blood glucose as a primary predictor of rheumatoid arthritis risk: a cross-sectional study in Iran.Osong public health and research perspectives · 2025Article
- A study of lipid profile peculiarities and atherogenic index of plasma in patients younger than fifty years of age with newly diagnosed rheumatoid arthritis.Journal of family medicine and primary care · 2025Article
- Review
- Cardiovascular disease detection using machine learning and carotid/femoral arterial imaging frameworks in rheumatoid arthritis patients.Rheumatology international · 2022Article
- Article
- Metabolic syndrome in rheumatoid arthritis patients: Relationship among its clinical components.Journal of clinical laboratory analysis · 2021Article
- Cardiovascular risk assessment in patients with rheumatoid arthritis using carotid ultrasound B-mode imaging.Rheumatology international · 2020Review
- The Lipid Paradox is present in ST-elevation but not in non-ST-elevation myocardial infarction patients: Insights from the Singapore Myocardial Infarction Registry.Scientific reports · 2020Observational
- The Roles of Lipoprotein in Psoriasis.International journal of molecular sciences · 2020Review
- Cardiovascular Risk in Psoriasis Patients: Clinical, Functional and Morphological Parameters.Arquivos brasileiros de cardiologia · 2019Observational
- The "cholesterol paradox" among inpatients - retrospective analysis of medical documentation.Archives of medical sciences. Atherosclerotic diseases · 2018Article
- Vascular inflammation and low-density lipoproteins: is cholesterol the link? A lesson from the clinical trials.British journal of pharmacology · 2017Review
- Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation.The Journal of pediatrics · 2016Article
- Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid Arthritis.PloS one · 2016Observational
- Review
- Lipid and Metabolic Changes in Rheumatoid Arthritis.Current rheumatology reports · 2015Review
- Blood lipids among young children in Europe: results from the European IDEFICS study.International journal of obesity (2005) · 2014Article
- Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis.Rheumatology (Oxford, England) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality, related not only to traditional CV risk factors, but also to a chronic inflammatory state. However, lipid profiles in RA are different from those observed in the general population at risk of CV disease, where there is evidence of a positive relationship between disease and high cholesterol levels. In untreated patients with active RA this relationship is different, with a paradoxical effect resulting in lower levels of cholesterol associated with an increased risk of CV disease. In this review, we summarize the latest evidence on lipid abnormalities in the setting of RA and the interaction between inflammation and lipoproteins, as well as the effect of DMARDs and biologic therapies on lipid profiles and the possible implications for CV outcomes in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.