ArticleLung2012
Primary pulmonary primitive neuroectodermal tumor (PNET): a clinicopathological and immunohistochemical study of six cases.
Article in Lung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Primary Ewing Sarcoma of the Lung: Integrative Analysis of Clinical, Histopathological, Immunohistochemical, and Cytogenetic Features with Literature Review.Indian journal of surgical oncology · 2026Article
- Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review.Journal of cardiothoracic surgery · 2024Review
- A rare radiotherapy-sensitive primitive neuroectodermal tumor withThe Journal of international medical research · 2022Review
- Primary Mediastinal Ewing sarcoma presenting as a massive lung lesion with a mediastinal shift.Clinical case reports · 2021Article
- Primary pulmonary Ewing's sarcoma: rare cause of massive hemothorax in a young girl-case report.BMC pediatrics · 2021Article
- Rare Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review.OncoTargets and therapy · 2021Article
- Primary pulmonary Ewing sarcoma/peripheral primitive neuroectodermal tumor.Proceedings (Baylor University. Medical Center) · 2020Article
- Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung.Internal medicine (Tokyo, Japan) · 2019Article
- Primary pericardial primitive neuroectodermal tumor: a case report and review of literature.International journal of clinical and experimental pathology · 2018Article
- Antiangiogenic therapy for primitive neuroectodermal tumor with thalidomide: A case report and review of literature.Medicine · 2017Review
- Classification of pulmonary neuroendocrine tumors: new insights.Translational lung cancer research · 2017Review
- Late onset of primary pulmonary primitive neuroectodermal tumor: a case report.Clujul medical (1957) · 2017Article
- Benefit of Sunitinib in the treatment of pulmonary primitive neuroectodermal tumors: a case report and literature review.Oncotarget · 2016Review
- Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: A case report.Thoracic cancer · 2016Article
- Primitive neuroectodermal tumor of lungs in adults: a rare series of three cases treated with upfront chemo-radiation.Translational lung cancer research · 2016Article
- Primary Multiple Pulmonary Primitive Neuroectodermal Tumor: Case Report and Literature Review.Medicine · 2015Article
- Primitive neuroectodermal tumor/ewing sarcoma presenting with pulmonary nodular lesions.Case reports in oncological medicine · 2015Article
- Primitive neuroectodermal tumor (PNET) of the lung in an adult woman.World journal of surgical oncology · 2014Article
- Three cases of a peripheral primitive neuroectodermal tumor diagnosed using computed tomography or magnetic resonance imaging.Oncology letters · 2013Article
- Thoracic primitive neuroectodermal tumor: an unusual case and literature review.Case reports in pulmonology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinicopathological and immunohistochemical features of six primary pulmonary primitive neuroectodermal tumors (PNETs) are reported.
methodsThe patients were four men and two women aged 22-56 years (mean = 32.3 years). The main presenting symptoms included chest pain, shortness of breath, and cough. The tumor size ranged from 4 to 9.6 cm.
resultsMacroscopically, the tumors were circumscribed, yellow-white in color, and of soft and friable consistency. Histologically, the lesions were composed of a monomorphic population of solidly packed round cells with a round-to-ovoid nucleus, fine chromatin, small nucleoli, and scanty pale cytoplasm. Immunohistochemically, the tumor cells were uniformly positive for CD99, neuron-specific enolase, and vimentin, and single cases focally expressed cytokeratin and S100. Fluorescence in situ hybridization analysis performed in two cases showed positive rearrangement for the EWSR1 gene at the 22q12 locus. Follow-up information available for four patients showed that three had died 24-54 months after diagnosis and one patient is alive 11 months after diagnosis. Two patients were lost to follow-up.
conclusionPrimary PNETs of the lung are rare tumors that need to be added to the differential diagnosis of primary pulmonary neoplasms composed of small cells. Awareness of this entity as a primary pulmonary neoplasm is required in order to avoid misdiagnosis and unsuitable treatment of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.