ReviewCellular and molecular life sciences : CMLS2012
Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.
Review in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages.International journal of molecular sciences · 2025Review
- Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis.Cardiovascular diabetology · 2023Article
- Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.Cellular and molecular life sciences : CMLS · 2022Article
- Review
- Calcium Regulation on the Atrial Regional Difference of Collagen Production Activity in Atrial Fibrogenesis.Biomedicines · 2021Article
- Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis.Journal of neuroinflammation · 2020Article
- ER stress increases store-operated CaThe Journal of biological chemistry · 2020Article
- Heterologous calcium-dependent inactivation of Orai1 by neighboring TRPV1 channels modulates cell migration and wound healing.Communications biology · 2019Article
- CRAC channel-based optogenetics.Cell calcium · 2018Review
- Resveratrol attenuates high glucose-induced endothelial cell apoptosis via mediation of store-operated calcium entry.Molecular and cellular biochemistry · 2018Article
- Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Store-Operated CaCurrent molecular biology reports · 2017Review
- Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1.PloS one · 2016Article
- Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells.Oncotarget · 2015Article
- Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.Gastroenterology · 2015Article
- Stromal interaction molecule 1 (STIM1) silencing inhibits tumor growth and promotes cell cycle arrest and apoptosis in hypopharyngeal carcinoma.Medical oncology (Northwood, London, England) · 2015Article
- Intracellular Ca2+ signaling and preimplantation development.Advances in experimental medicine and biology · 2015Review
- The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.Frontiers in cellular neuroscience · 2015Article
- A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).The Journal of biological chemistry · 2014Article
- Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Store-operated Ca(2+) entry describes the phenomenon that connects a depletion of internal Ca(2+) stores to an activation of plasma membrane-located Ca(2+) selective ion channels. Tremendous progress towards the underlying molecular mechanism came with the discovery of the two respective limiting components, STIM and Orai. STIM1 represents the ER-located Ca(2+) sensor and transmits the signal of store depletion to the plasma membrane. Here it couples to and activates Orai, the highly Ca(2+)-selective pore-forming subunit of Ca(2+) release-activated Ca(2+) channels. In this review, we focus on the molecular steps that these two proteins undergo from store-depletion to their coupling, the activation, and regulation of Ca(2+) currents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.