ReviewCurrent opinion in nephrology and hypertension2012
Management approaches to hypertension in autonomic failure.
Review in Current opinion in nephrology and hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation and Treatment of Autonomic Failure.
The Pathophysiology and Treatment of Supine Hypertension in Patients With Autonomic Failure
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Evaluation and treatment of orthostatic hypotension.Journal of the American Society of Hypertension : JASHGuideline
- Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa.Hypertension (Dallas, Tex. : 1979) · 2015Trial
- Orthostatic Blood Pressure, Cardiovascular Disease, and Hypotensive Events.Hypertension (Dallas, Tex. : 1979) · 2026Article
- The power of positioning: managing severe autonomic dysreflexia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions.Journal of neurology · 2023Review
- Renal Transplantation in Pure Autonomic Failure.Transplantation direct · 2022Article
- Blood pressure regulation in autonomic failure by dietary sodium, blood volume and posture.Autonomic neuroscience : basic & clinical · 2021Article
- Dysautonomia: A Forgotten Condition - Part II.Arquivos brasileiros de cardiologia · 2021Article
- Pharmacologic treatment of orthostatic hypotension.Autonomic neuroscience : basic & clinical · 2020Review
- Clinical Trials for Neurogenic Orthostatic Hypotension: A Comprehensive Review of Endpoints, Pitfalls, and Challenges.Seminars in neurology · 2020Review
- Management of Orthostatic Hypotension.Continuum (Minneapolis, Minn.) · 2020Review
- Orthostatic Hypotension in Parkinson Disease.Clinics in geriatric medicine · 2020Review
- Syndrome of Supine Hypertension with Orthostatic Hypotension: Pathophysiology and Clinical Approach.Current cardiology reviews · 2020Review
- Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Blood pressure circadian rhythm alterations in alpha-synucleinopathies.Journal of neurology · 2019Article
- The Autonomic Regulation of Circulation and Adverse Events in Hypertensive Patients during Follow-Up Study.Cardiology research and practice · 2019Article
- Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS) : Endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Review
- Clinical characteristics of supine hypertension in de novo Parkinson disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewSupine hypertension is a common finding in autonomic failure that can worsen orthostatic hypotension and predispose to end-organ damage. This review focuses on nonpharmacologic and pharmacologic approaches to manage hypertension in these patients in the face of disabling orthostatic hypotension. RECENT
findingsThe hypertension of autonomic failure can be driven by sympathetic-dependent or independent mechanisms, contingent on the site of autonomic lesions. Management of supine hypertension should include simple nonpharmacologic approaches including avoiding the supine position during the daytime and sleeping in a head-up tilt position at night. Most patients, however, require pharmacologic treatment. Several antihypertensive therapies lower nighttime pressure in autonomic failure, but none improve nocturnal volume depletion or morning orthostatic tolerance. Regardless, treatment may still be beneficial in some patients but must be decided on an individual basis. Blood pressure monitoring is helpful in this regard, as well as titration of doses, as these patients are hypersensitive to depressor agents due to loss of baroreceptor reflexes. SUMMARY: Autonomic failure provides a unique opportunity to study blood pressure regulation independent of autonomic influences. Understanding mechanisms driving supine hypertension will have important implications for the treatment of autonomic failure and will improve our knowledge of cardiovascular regulation in other populations, including essential hypertension and elderly hypertensive individuals with comorbid orthostatic hypotension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.