ReviewMolecular psychiatry2013
Translational approaches to the biology of Autism: false dawn or a new era?
Review in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Resting-state EEG power differences in autism spectrum disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Analysis of the Pupillary Light Reflex Response Against Light Stimuli for Autism Screening in Children.Journal of autism and developmental disorders · 2026Article
- Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.Brain imaging and behavior · 2025Article
- Deep Canonical Correlation Fusion Algorithm Based on Denoising Autoencoder for ASD Diagnosis and Pathogenic Brain Region Identification.Interdisciplinary sciences, computational life sciences · 2024Article
- CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural induction.HGG advances · 2024Article
- Hidden regulators: the emerging roles of lncRNAs in brain development and disease.Frontiers in neuroscience · 2024Review
- Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies.Frontiers in neuroscience · 2024Review
- Low Plasma Levels of Contactin-Associated Protein-Like 2 in Children with Autism Spectrum Disorder: Links to Neural Development.Neuropsychiatric disease and treatment · 2024Article
- CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors.Signal transduction and targeted therapy · 2023Article
- Social Deficits or Interactional Differences? Interrogating Perspectives on Social Functioning in Autism.Frontiers in psychiatry · 2022Article
- Cognitive theories of autism based on the interactions between brain functional networks.Frontiers in human neuroscience · 2022Article
- Brain structural alterations in autism and criminal psychopathy.NeuroImage. Clinical · 2022Article
- Granger Causality among Graphs and Application to Functional Brain Connectivity in Autism Spectrum Disorder.Entropy (Basel, Switzerland) · 2021Article
- Age-related differences in white matter diffusion measures in autism spectrum condition.Molecular autism · 2020Article
- Dysregulation of neuron differentiation in an autistic savant with exceptional memory.Molecular brain · 2019Article
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.Cellular and molecular neurobiology · 2019Article
- Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity.Human brain mapping · 2019Article
- Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism.Frontiers in psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Discovering novel treatments for Autism Spectrum Disorders (ASD) is a challenge. Its etiology and pathology remain largely unknown, the condition shows wide clinical diversity, and case identification is still solely based on symptomatology. Hence clinical trials typically include samples of biologically and clinically heterogeneous individuals. 'Core deficits', that is, deficits common to all individuals with ASD, are thus inherently difficult to find. Nevertheless, recent reports suggest that new opportunities are emerging, which may help develop new treatments and biomarkers for the condition. Most important, several risk gene variants have now been identified that significantly contribute to ASD susceptibility, many linked to synaptic functioning, excitation-inhibition balance, and brain connectivity. Second, neuroimaging studies have advanced our understanding of the 'wider' neural systems underlying ASD; and significantly contributed to our knowledge of the complex neurobiology associated with the condition. Last, the recent development of powerful multivariate analytical techniques now enable us to use multi-modal information in order to develop complex 'biomarker systems', which may in the future be used to assist the behavioral diagnosis, aid patient stratification and predict response to treatment/intervention. The aim of this review is, therefore, to summarize some of these important new findings and highlight their potential significant translational value to the future of ASD research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.