ArticleProstate cancer and prostatic diseases2012
Identification of genetic risk associated with prostate cancer using ancestry informative markers.
Article in Prostate cancer and prostatic diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Genetic Ancestry and Colorectal Cancer in the All of Us Dataset.JAMA network open · 2026Article
- Integrative multi-omics profiling of colorectal cancer from a Hispanic/Latino cohort of patients.medRxiv : the preprint server for health sciences · 2024Article
- Strengthening Capacity for Prostate Cancer Early Diagnosis in West Africa Amidst the COVID-19 Pandemic: A Realist Approach to Rethinking and Operationalizing the World Health Organization 2017 Guide to Cancer Early Diagnosis.Annals of global health · 2022Article
- Relationship between West African ancestry with lung cancer risk and survival in African Americans.Cancer causes & control : CCC · 2019Article
- Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos.Human genomics · 2019Article
- Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.The Prostate · 2017Article
- Population Genomics and the Statistical Values of Race: An Interdisciplinary Perspective on the Biological Classification of Human Populations and Implications for Clinical Genetic Epidemiological Research.Frontiers in genetics · 2016Review
- Interest in genomic SNP testing for prostate cancer risk: a pilot survey.Hereditary cancer in clinical practice · 2015Article
- Ancestry-informative markers for African Americans based on the Affymetrix Pan-African genotyping array.PeerJ · 2014Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans.Cancer genomics & proteomicsArticle
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundProstate cancer (PCa) is a common malignancy and a leading cause of cancer death among men in the United States with African-American (AA) men having the highest incidence and mortality rates. Given recent results from admixture mapping and genome-wide association studies for PCa in AA men, it is clear that many risk alleles are enriched in men with West African genetic ancestry.
methodsA total of 77 ancestry informative markers (AIMs) within surrounding candidate gene regions were genotyped and haplotyped using Pyrosequencing in 358 unrelated men enrolled in a PCa genetic association study at the Howard University Hospital between 2000 and 2004. Sequence analysis of promoter region single-nucleotide polymorphisms (SNPs) to evaluate disruption of transcription factor-binding sites was conducted using in silico methods.
resultsEight AIMs were significantly associated with PCa risk after adjusting for age and West African ancestry. SNP rs1993973 (intervening sequences) had the strongest association with PCa using the log-additive genetic model (P=0.002). SNPs rs1561131 (genotypic, P=0.007), rs1963562 (dominant, P=0.01) and rs615382 (recessive, P=0.009) remained highly significant after adjusting for both age and ancestry. We also tested the independent effect of each significantly associated SNP and rs1561131 (P=0.04) and rs1963562 (P=0.04) remained significantly associated with PCa development. After multiple comparisons testing using the false discovery rate, rs1993973 remained significant. Analysis of the rs156113-, rs1963562-rs615382l and rs1993973-rs585224 haplotypes revealed that the least frequently found haplotypes in this population were significantly associated with a decreased risk of PCa (P=0.032 and 0.0017, respectively).
conclusionsThe approach for SNP selection utilized herein showed that AIMs may not only leverage increased linkage disequilibrium in populations to identify risk and protective alleles, but may also be informative in dissecting the biology of PCa and other health disparities.
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