ArticleCirculation2012
Early predictors of survival to and after heart transplantation in children with dilated cardiomyopathy.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Corticosteroids for viral myocarditis.The Cochrane database of systematic reviews · 2013Pooled it
- Evaluation of Pediatric Cardiomyopathy Patients in Pediatric Intensive Care Unit.Turkish archives of pediatrics · 2025Article
- A comparative review of myocarditis in pediatrics versus adults: pathogenesis, diagnosis, and management.Frontiers in immunology · 2025Review
- Pathology of explanted pediatric hearts: An 11-year study. Population characteristics and implications for outcomes.Pediatric transplantation · 2024Article
- Pediatric dilated cardiomyopathy: a review of current clinical approaches and pathogenesis.Frontiers in pediatrics · 2024Review
- Review
- Findings and Outcome of Transcatheter Right Ventricular Endomyocardial Biopsy and Hemodynamic Assessment in Children with Suspected Myocarditis or Cardiomyopathy.International journal of environmental research and public health · 2022Article
- Addressing Chemotherapy-Induced Peripheral Neuropathy Using Multi-Frequency Vibrometry and Patient-Reported Outcomes.Journal of clinical medicine · 2022Article
- Endomyocardial Biopsy in Pediatric Myocarditis and Dilated Cardiomyopathy: A Tool in Search for a Role.Journal of cardiovascular development and disease · 2022Review
- Racial Disparities in Hospital Mortality Among Pediatric Cardiomyopathy and Myocarditis Patients.Pediatric cardiology · 2021Article
- Aetiology and 30-Year Long-Term Outcome of Children with Cardiomyopathy Necessitating Heart Transplantation.Journal of personalized medicine · 2020Article
- Pediatric heart transplantation: long-term outcomes.Indian journal of thoracic and cardiovascular surgery · 2020Review
- Circulating Long Non-coding RNA ENST00000507296 Is a Prognostic Indicator in Patients with Dilated Cardiomyopathy.Molecular therapy. Nucleic acids · 2019Article
- Sca-1European journal of immunology · 2018Article
- Current state of pediatric cardiac transplantation.Annals of cardiothoracic surgery · 2018Review
- Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy.The Journal of experimental medicine · 2017Article
- Evaluation of the diagnostic work-up in children with myocarditis and idiopathic dilated cardiomyopathy.Pediatric cardiology · 2015Article
- Pediatric heart transplantation-indications and outcomes in the current era.Journal of thoracic disease · 2014Review
- Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.The Journal of experimental medicine · 2014Article
- Severity of mitral regurgitation predicts risk of death or cardiac transplantation in children with idiopathic dilated cardiomyopathy.Pediatric cardiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe importance of clinical presentation and pretransplantation course on outcome in children with dilated cardiomyopathy listed for heart transplantation is not well defined. METHODS AND
resultsThe impact of age, duration of illness, sex, race, ventricular geometry, and diagnosis of myocarditis on outcome in 261 children with dilated cardiomyopathy enrolled in the Pediatric Cardiomyopathy Registry and Pediatric Heart Transplant Study was studied. End points included listing as United Network for Organ Sharing status 1, death while waiting, and death after transplantation. The median age at the time of diagnosis was 3.4 years, and the mean time from diagnosis to listing was 0.62±1.3 years. Risk factors associated with death while waiting were ventilator use and older age at listing in patients not mechanically ventilated (P=0.0006 and P=0.03, respectively). Shorter duration of illness (P=0.04) was associated with listing as United Network for Organ Sharing status 1. Death after transplantation was associated with myocarditis at presentation (P=0.009), nonwhite race (P<0.0001), and a lower left ventricular end-diastolic dimension z score at presentation (P=0.04). In the myocarditis group, 17% (4 of 23) died of acute rejection after transplantation.
conclusionsMechanical ventilator use and older age at listing predicted death while waiting, whereas nonwhite race, smaller left ventricular dimension, and myocarditis were associated with death after transplantation. Although 97% of children with clinically or biopsy-diagnosed myocarditis at presentation survived to transplantation, they had significantly higher posttransplantation mortality compared with children without myocarditis, raising the possibility that preexisting viral infection or inflammation adversely affects graft survival.
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Registered trials
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