ArticleBMC cardiovascular disorders2012
Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study.
Article in BMC cardiovascular disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness.PloS one · 2021Pooled it
- Shear wave elastography to evaluate the effect of serum uric acid levels on carotid artery elasticity in patients with high-normal blood pressure.Journal of medical biochemistry · 2025Article
- Association between serum uric acid levels and arterial stiffness in patients with psoriasis.Archives of dermatological research · 2025Article
- Sex-specific associations between prolonged serum uric acid levels and risk of major adverse cardiovascular events.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Gender Influence on XOR Activities and Related Pathologies: A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Association between elevated carotid intima-media thickness and serum uric acid levels among patients with essential hypertension in primary care setting in Sungai Buloh, Malaysia.International journal of clinical practice · 2021Article
- Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population.Journal of clinical medicine · 2020Article
- Uric Acid and Arterial Stiffness.Therapeutics and clinical risk management · 2020Review
- An Inverse Relationship between Hyperuricemia and Mortality in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis.Journal of clinical medicine · 2018Article
- Article
- Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort.Clinical rheumatology · 2017Article
- Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening in Korean population.PloS one · 2017Article
- Evaluation of cardiovascular risk in stages of gout by a complex multimodal ultrasonography.Rheumatology international · 2017Article
- Ultrasonographic measurement of carotid artery resistive index and diastolic function of the heart in gout patients.Rheumatology international · 2015Article
- Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.Annals of the rheumatic diseases · 2015Article
- Gender influences the relationship between lung function and cardiac remodeling in hypertensive subjects.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Association of hyperuricemia with conventional cardiovascular risk factors in elderly patients.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China.BMC cardiovascular disorders · 2014Article
- Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure.International journal of cardiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women.
methodsThree hundred and thirty eight patients (207 women and 131 men) were cross-sectionally evaluated by clinical, laboratory, hemodynamic and carotid ultrasound analysis. Common carotid diameters, circumferential wall tensions, Young's Elastic Modulus, Stiffness Index, Arterial Compliance and intima-media thickness (IMT) were determined. Internal carotid artery resistive index (ICRI), a hemodynamic measure that reflects local vascular impedance and microangiopathy, was also assessed.
resultsUnivariate analysis showed no significant correlation of SUA with carotid diameters, elasticity/stiffness indexes, IMT and circumferential wall tensions in both genders. Conversely, SUA correlated with ICRI (r=0.34; p<0.001) in women, but not in men, and hyperuricemic women presented higher ICRI than normouricemic ones (0.684 ± 0.007 vs. 0.649 ± 0.004; p<0.001). Stepwise and logistic regression analyses adjusted for potential confounding factors showed that ICRI was independently associated with SUA and hyperuricemia in women.
conclusionsThis study demonstrated that SUA was associated with ICRI in hypertensive women, suggesting that there might gender-related differences in the relationship between SUA and vascular damage in subjects with systemic hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.