Evidence map›Paper›PMID 22800091›Full record

ArticleLeukemia & lymphoma2013

Examining racial differences in diffuse large B-cell lymphoma presentation and survival.

Christopher R Flowers, Pareen J Shenoy, Uma Borate, Kevin Bumpers, Tanyanika Douglas-Holland, Nassoma King, Otis W Brawley, Joseph Lipscomb, Mary Jo Lechowicz, Rajni Sinha and 8 more

Open access · greenAbstract read
In one paragraph

Article in Leukemia & lymphoma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Christopher R FlowersDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Pareen J Shenoy
Uma Borate
Kevin Bumpers
Tanyanika Douglas-Holland
Nassoma King
Otis W Brawley
Joseph Lipscomb
Mary Jo Lechowicz
Rajni Sinha
Rajinder S Grover
Leon Bernal-Mizrachi
Jeanne Kowalski
Will Donnellan
Angelina The
Vishnu Reddy
David L Jaye
James Foran
Winship Cancer InstituteEmory University · USAmerican Cancer Society · USMayo Clinic in Florida · USUniversity of Alabama at Birmingham · US

Funding

Biological Variants Underlying Racial Differences in LymphomaR21CA158686 · NCI · EMORY UNIVERSITY · PI FLOWERS, CHRISTOPHER R · 2012 to 2013
$371k
NCI NIH HHS R21 CA158686NCI NIH HHS R21CA158686
6 · The paper itself

Abstract

We performed a retrospective cohort analysis of 701 (533 white and 144 black) patients with diffuse large B-cell lymphoma (DLBCL) treated at two referral centers in southern United States between 1981 and 2010. Median age of diagnosis for blacks was 50 years vs. 57 years for whites (p < 0.001). A greater percentage of blacks presented with elevated lactate dehydrogenase levels, B-symptoms and performance status ≥ 2. More whites (8%) than blacks (3%) had a positive family history of lymphoma (p = 0.048). There were no racial differences in the use of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; 52% black vs. 47% white, p = 0.73). While black race predicted worse survival among patients treated with CHOP (hazard ratio [HR] 1.8, p < 0.001), treatment with R-CHOP was associated with improved survival irrespective of race (HR 0.61, p = 0.01). Future studies should examine biological differences that may underlie the observed racial differences in presentation and outcome.

Indexed as

Black PeopleWhite PeopleAdultAgedAntineoplastic Combined Chemotherapy ProtocolsHumansLymphoma, Large B-Cell, DiffuseMiddle AgedNeoplasm StagingRetrospective StudiesYoung Adult

Identifiers

PMID22800091
PMCPMC4151307
OpenAlexW2005748493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.