ArticleJournal of leukocyte biology2012
Type II NKT cells facilitate Alum-sensing and humoral immunity.
Article in Journal of leukocyte biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines.Vaccines · 2021Article
- Use of aFrontiers in immunology · 2021Article
- DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.JCI insight · 2020Article
- EAACI Allergen Immunotherapy User's Guide.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Review
- The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens.Frontiers in immunology · 2018Review
- Type II NKT Cells and Their Emerging Role in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset.Immunogenetics · 2016Review
- CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation.International immunology · 2015Article
- The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions.Frontiers in immunology · 2015Review
- Recognition of lysophosphatidylcholine by type II NKT cells and protection from an inflammatory liver disease.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Critical role of NKT cells in posttransplant alloantibody production.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Article
- Influenza vaccines: a moving interdisciplinary field.Viruses · 2014Review
- Key roles of adjuvants in modern vaccines.Nature medicine · 2013Review
- Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.International reviews of immunology · 2013Review
- Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype.Immune network · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Alum-based adjuvants facilitate vaccine-driven humoral immunity, but their mechanism of action remains poorly understood. Herein, we report that lack of type II NKT cells is associated with intact, mature B cells but dampened humoral immunity following immunization with Alum-adsorbed T-dependent antigen. Type II NKT cells facilitated production of IL-4, IL-5, IL-10, IL-13, and antibody by LN and splenocyte cultures following Alum/antigen administration in vivo and antigen restimulation in vitro. Addition of IL-4 and IL-5 to type II NKT-deficient cultures restored in vitro antibody production. Intracellular staining revealed that Alum-primed type II NKT cells coordinated IL-4 secretion by T cells. Alum did not significantly affect CD1d expression in vivo, but addition of CD1d-blocking mAb diminished cytokine production and in vitro antibody production. Type II NKT cells therefore function as part of the Alum-sensing apparatus and in a CD1d-dependent manner, facilitate T(H)2-driven humoral immunity. This may have important consequences for understanding the mechanism of action of Alum-containing vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.