ArticleNucleic acids research2012
The co-regulation mechanism of transcription factors in the human gene regulatory network.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells.PLoS genetics · 2026Article
- Unveiling causal regulatory mechanisms through cell-state parallax.Nature communications · 2025Article
- CoTF-reg reveals cooperative transcription factors in oligodendrocyte gene regulation using single-cell multi-omics.Communications biology · 2025Article
- Mechanistic Modeling the Role of MicroRNAs and Transcription Factors in Disease Progression.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Causal gene regulatory analysis with RNA velocity reveals an interplay between slow and fast transcription factors.Cell systems · 2024Article
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- Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use.Brain, behavior, & immunity - health · 2022Article
- Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes.Nucleic acids research · 2022Article
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- TENET: gene network reconstruction using transfer entropy reveals key regulatory factors from single cell transcriptomic data.Nucleic acids research · 2021Article
- Construction of Condition-Specific Gene Regulatory Network Using Kernel Canonical Correlation Analysis.Frontiers in genetics · 2021Article
- Aberrant Expression of PAFAH1B3 Affects Proliferation and Apoptosis in Osteosarcoma.Frontiers in oncology · 2021Article
- Saline stress affects the pH-dependent regulation of the transcription factor PacC in the dermatophyte Trichophyton interdigitale.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis.Oncogene · 2018Article
- Identification of regulatory modules in genome scale transcription regulatory networks.BMC systems biology · 2017Article
- Dynamic and Modularized MicroRNA Regulation and Its Implication in Human Cancers.Scientific reports · 2017Article
- Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series).Pulmonary circulation · 2016Review
- Integrative systems analysis of diet-induced obesity identified a critical transition in the transcriptomes of the murine liver and epididymal white adipose tissue.International journal of obesity (2005) · 2016Article
- Article
- From System-Wide Differential Gene Expression to Perturbed Regulatory Factors: A Combinatorial Approach.PloS one · 2015Article
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6 authors.
Funding
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Abstract
The co-regulation of transcription factors (TFs) has been widely observed in various species. Why is such a co-regulation mechanism needed for transcriptional regulation? To answer this question, the following experiments and analyses were performed. First, examination of the human gene regulatory network (GRN) indicated that co-regulation was significantly enriched in the human GRN. Second, mathematical simulation of an artificial regulatory network showed that the co-regulation mechanism was related to the biphasic dose-response patterns of TFs. Third, the relationship between the co-regulation mechanism and the biphasic dose-response pattern was confirmed using microarray experiments examining different time points and different doses of the toxicant tetrachlorodibenzodioxin. Finally, two mathematical models were constructed to mimic highly co-regulated networks (HCNs) and little co-regulated networks (LCNs), and we found that HCNs were more robust to parameter perturbation than LCNs, whereas LCNs were faster in adaptation to environmental changes than HCNs.
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