ArticleExperimental physiology2013
α1-Adrenergic responsiveness in human skeletal muscle feed arteries: the impact of reducing extracellular pH.
Article in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
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- The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis.International journal of molecular sciences · 2022Review
- Characterization of Systemic and Regional Hemodynamics and Vascular Dysfunction in Mice with Fecal Induced Peritonitis.Biomedicines · 2022Article
- Vasodilatory and vascular mitochondrial respiratory function with advancing age: evidence of a free radically mediated link in the human vasculature.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Improved Survival With Extracorporeal Cardiopulmonary Resuscitation Despite Progressive Metabolic Derangement Associated With Prolonged Resuscitation.Circulation · 2020Article
- Vasoreactivity of the Murine External Jugular Vein and Carotid Artery.Journal of vascular research · 2020Article
- Vascular mitochondrial respiratory function: the impact of advancing age.American journal of physiology. Heart and circulatory physiology · 2018Article
- Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy.Journal of visualized experiments : JoVE · 2017Article
- TRPVExperimental physiology · 2017Article
- Experimental reduction of miR-92a mimics arterial aging.Experimental gerontology · 2016Article
- Age-related arterial telomere uncapping and senescence is greater in women compared with men.Experimental gerontology · 2016Article
- Interactive effect of acute sympathetic activation and exercise intensity on the dynamic response characteristics of vascular conductance in the human calf muscle.European journal of applied physiology · 2015Article
- Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside.Critical care (London, England) · 2015Article
- α1- and α2-adrenergic responsiveness in human skeletal muscle feed arteries: the role of TRPV ion channels in heat-induced sympatholysis.American journal of physiology. Heart and circulatory physiology · 2014Article
- Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping.Journal of hypertension · 2014Article
- Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries.Pflugers Archiv : European journal of physiology · 2014Article
- Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries.American journal of physiology. Heart and circulatory physiology · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Graded exercise results not only in the modulation of adrenergic mediated smooth muscle tone and a preferential increase in blood flow to the active skeletal muscle termed 'functional sympatholysis', but is also paralleled by metabolically induced reductions in pH. We therefore sought to determine whether pH attenuates α(1)-adrenergic receptor sensitivity in human feed arteries. Feed arteries (560 ± 31 μm i.d.) were harvested from 24 humans (55 ± 4 years old) and studied using the isometric tension technique. Vessel function was assessed using KCl, phenylephrine (PE), ACh and sodium nitroprusside (SNP) concentration-response curves to characterize non-receptor-mediated and receptor-mediated vasocontraction, as well as endothelium-dependent and -independent vasorelaxation, respectively. All concentration-response curves were obtained from (originally contiguous) vessel rings in separate baths with a pH of 7.4, 7.1, 6.8 or 6.5. Reduction of the pH, via HCl, reduced maximal PE-induced vasocontraction (pH 7.4 = 85 ± 19, pH 7.1 = 57 ± 16, pH 6.8 = 34 ± 15 and pH 6.5 = 16 ± 5% KCl(max)), which was partly due to reduced smooth muscle function, as assessed by KCl (pH 7.4 = 88 ± 13, pH 7.1 = 67 ± 8, pH 6.8 = 67 ± 9 and pH 6.5 = 58 ± 8% KCl(max)). Graded acidosis had no effect on maximal vasorelaxation. In summary, these data reveal that reductions in extracellular pH attenuate α(1)-mediated vasocontraction, which is partly explained by reduced smooth muscle function, although vasorelaxation in response to ACh and SNP remained intact. These findings support the concept that local acidosis is likely to contribute to functional sympatholysis and exercise hyperaemia by opposing sympathetically mediated vasoconstriction while not impacting vasodilatation.
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