ArticleEukaryotic cell2012
Mitochondrial carnitine-dependent acetyl coenzyme A transport is required for normal sexual and asexual development of the ascomycete Gibberella zeae.
Article in Eukaryotic cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Strategies for Controlling the Sporulation inJournal of fungi (Basel, Switzerland) · 2022Review
- The essential role of fungal peroxisomes in plant infection.Molecular plant pathology · 2022Review
- Involvement of the two L-lactate dehydrogenase in development and pathogenicity in Fusarium graminearum.Current genetics · 2019Article
- Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production inBiotechnology for biofuels · 2019Article
- Article
- Genome-wide exonic small interference RNA-mediated gene silencing regulates sexual reproduction in the homothallic fungus Fusarium graminearum.PLoS genetics · 2017Article
- Article
- Comparative transcriptome analysis between an evolved abscisic acid-overproducing mutant Botrytis cinerea TBC-A and its ancestral strain Botrytis cinerea TBC-6.Scientific reports · 2016Article
- Functional characterization of sucrose non-fermenting 1 protein kinase complex genes in the Ascomycete Fusarium graminearum.Current genetics · 2014Article
- WetA is required for conidiogenesis and conidium maturation in the ascomycete fungus Fusarium graminearum.Eukaryotic cell · 2014Article
- Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum.Toxins · 2013Article
- Peroxisomes and sexual development in fungi.Frontiers in physiology · 2013Review
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi have evolved efficient metabolic mechanisms for the exact temporal (developmental stages) and spatial (organelles) production of acetyl coenzyme A (acetyl-CoA). We previously demonstrated mechanistic roles of several acetyl-CoA synthetic enzymes, namely, ATP citrate lyase and acetyl-CoA synthetases (ACSs), in the plant-pathogenic fungus Gibberella zeae. In this study, we characterized two carnitine acetyltransferases (CATs; CAT1 and CAT2) to obtain a better understanding of the metabolic processes occurring in G. zeae. We found that CAT1 functioned as an alternative source of acetyl-CoA required for lipid accumulation in an ACS1 deletion mutant. Moreover, deletion of CAT1 and/or CAT2 resulted in various defects, including changes to vegetative growth, asexual/sexual development, trichothecene production, and virulence. Although CAT1 is associated primarily with peroxisomal CAT function, mislocalization experiments showed that the role of CAT1 in acetyl-CoA transport between the mitochondria and cytosol is important for sexual and asexual development in G. zeae. Taking these data together, we concluded that G. zeae CATs are responsible for facilitating the exchange of acetyl-CoA across intracellular membranes, particularly between the mitochondria and the cytosol, during various developmental stages.
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