ArticleMolecular biology and evolution2012
Environmental adaptation contributes to gene polymorphism across the Arabidopsis thaliana genome.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Patterns of Change in Nucleotide Diversity Over Gene Length.Genome biology and evolution · 2024Article
- Impacts of Natural Selection on Evolution of Core and Symbiotically Specialized (International journal of molecular sciences · 2023Article
- BLSSpeller to discover novel regulatory motifs in maize.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
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- Genomic Scans across Three Eucalypts Suggest that Adaptation to Aridity is a Genome-Wide Phenomenon.Genome biology and evolution · 2017Article
- Evidence of the Complexity of Gene Expression Analysis in Fish Wild Populations.International journal of genomics · 2017Article
- Environmental versus geographical effects on genomic variation in wild soybean (Glycine soja) across its native range in northeast Asia.Ecology and evolution · 2016Article
- Evolutionary potential and adaptation of Banksia attenuata (Proteaceae) to climate and fire regime in southwestern Australia, a global biodiversity hotspot.Scientific reports · 2016Article
- Molecular Evidence for Functional Divergence and Decay of a Transcription Factor Derived from Whole-Genome Duplication in Arabidopsis thaliana.Plant physiology · 2015Article
- Direct and indirect selection on flowering time, water-use efficiency (WUE, δ (13)C), and WUE plasticity to drought in Arabidopsis thaliana.Ecology and evolution · 2014Article
- Using genomics to characterize evolutionary potential for conservation of wild populations.Evolutionary applications · 2014Article
- Keeping it local: evidence for positive selection in Swedish Arabidopsis thaliana.Molecular biology and evolution · 2014Article
- The impact of linked selection on plant genomic variation.Briefings in functional genomics · 2014Article
- Article
- Strong selection genome-wide enhances fitness trade-offs across environments and episodes of selection.Evolution; international journal of organic evolution · 2014Article
- Maintenance of genetic diversity through plant-herbivore interactions.Current opinion in plant biology · 2013Review
- Intraspecific sequence variation and differential expression in starch synthase genes of Arabidopsis thaliana.BMC research notes · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The level of within-species polymorphism differs greatly among genes in a genome. Many genomic studies have investigated the relationship between gene polymorphism and factors such as recombination rate or expression pattern. However, the polymorphism of a gene is affected not only by its physical properties or functional constraints but also by natural selection on organisms in their environments. Specifically, if functionally divergent alleles enable adaptation to different environments, locus-specific polymorphism may be maintained by spatially heterogeneous natural selection. To test this hypothesis and estimate the extent to which environmental selection shapes the pattern of genome-wide polymorphism, we define the "environmental relevance" of a gene as the proportion of genetic variation explained by environmental factors, after controlling for population structure. We found substantial effects of environmental relevance on patterns of polymorphism among genes. In addition, the correlation between environmental relevance and gene polymorphism is positive, consistent with the expectation that balancing selection among heterogeneous environments maintains genetic variation at ecologically important genes. Comparison of the gene ontology annotations shows that genes with high environmental relevance are enriched in unknown function categories. These results suggest an important role for environmental factors in shaping genome-wide patterns of polymorphism and indicate another direction of genomic study.
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