Trial reportJournal of assisted reproduction and genetics2012
The relationship between pregnancy and oxidative stress markers on patients undergoing ovarian stimulations.
Trial report in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Comparison of DNA damage in granulosa cells of women undergoing controlled ovarian stimulation in in vitro fertilization protocols with the recombinant human follicle-stimulating hormones CorneumonArchives of gynecology and obstetrics · 2024Trial
- Oxidative stress biomarkers in assisted reproductive technologies: From follicular redox biology to clinical translation.Redox biology · 2026Review
- Augmented-OvSynch enhances estrus resumption, luteal function, and conception rates in postpartum Zebu crossbred cows under tropical smallholder systems.Veterinary world · 2025Article
- Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.Health science reports · 2025Review
- Urinary benzophenone-3 concentrations and ovarian reserve in a cohort of subfertile women.Fertility and sterility · 2024Article
- Different doses of recombinant FSH and determining parameters of oxidative stress.Journal of medical biochemistry · 2024Article
- Altered Energy Metabolism, Mitochondrial Dysfunction, and Redox Imbalance Influencing Reproductive Performance in Granulosa Cells and Oocyte During Aging.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes.Metabolites · 2024Article
- Serum and follicular fluid metabolome and markers of ovarian stimulation.Human reproduction (Oxford, England) · 2023Article
- Markers of Oxidative Stress in Obstetrics and Gynaecology-A Systematic Literature Review.Antioxidants (Basel, Switzerland) · 2022Review
- The Impact of Controlled Ovarian Stimulation on Serum Oxidative Stress Markers in Infertile Women with Endometriosis Undergoing ICSI.Antioxidants (Basel, Switzerland) · 2022Article
- Effects of multicycle gonadotropin-releasing hormone antagonist protocols on oxidative stress of follicular fluid and ovarian granulosa cells.Human cell · 2021Article
- Follicular fluid oxidative stress biomarkers and ART outcomes in PCOS women undergoing in vitro fertilization: A cross-sectional study.International journal of reproductive biomedicine · 2021Article
- Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predictAnnals of translational medicine · 2020Article
- Estradiol and Progesterone Levels are Related to Redox Status in the Follicular Fluid DuringJournal of the Endocrine Society · 2020Article
- Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Oxidative Stress Markers in GnRH Agonist and Antagonist Protocols in IVF.Journal of medical biochemistry · 2017Article
- Paraoxonase-1 enzyme activity assay for clinical samples: validation and correlation studies.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF.Journal of assisted reproduction and genetics · 2015Article
- Serum tumor necrosis factor-α, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility.Journal of assisted reproduction and genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the activities and relevance of a validated panel of antioxidant enzymes, cytokines, specific lipid peroxidation end products and six fatty acids by correlational analyses with peak E(2) levels and pregnancy outcome after ovarian stimulation for IVF or IUI.
methodsBlood samples obtained from 15 patients undergoing ovarian stimulation with rFSH or hMG were divided into two groups. Group-1 was baseline blood collected on day-2-3 of women cycle. Group-2 is blood collected at the end of FSH/hMG injection. Serum was collected and stored in liquid nitrogen at -196 °C until analysis. Standard IVF and IUI procedures were followed. The serum levels of Paraoxonase (PON1), Superoxide Dismutases (SOD), Interleukin-6 (IL-6), Glutathione Peroxidase (GPx), 8-Isoprostane, and fatty acids Arachidic, Palmitic, Stearic, Oleic, Linoleic & Linolenic were measured.
resultsWith the exception of 8-Isoprostane, results showed a positive correlation between baseline and peak levels of E(2) and that of SOD, GPx, PON1, and IL-6. The PON1, IL-6 and SOD were significantly (p < 0.05) higher in pregnant than non-pregnant group. Fatty acid levels at baseline and peak E(2) were not different but pregnancy rates were found to be decreasing with higher palmitic, and stearic acid levels.
conclusionsOvarian stimulation causes a significant increase in serum PON1, SOD, GPx and IL-6 activity in women undergoing IVF or IUI. The high levels of IL-6, SOD, and PON1 and lower levels of palmitic, and stearic acids in the pregnancy positive group indicate that these oxidative stress and nutritional factors may be used as a predictive marker in controlled ovarian stimulation success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.