ArticleAdvances in nutrition (Bethesda, Md.)2012
Implications of malaria on iron deficiency control strategies.
Article in Advances in nutrition (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations.The Cochrane database of systematic reviews · 2021Pooled it
- Wheat flour fortification with iron for reducing anaemia and improving iron status in populations.The Cochrane database of systematic reviews · 2020Pooled it
- Effect of a short course of iron polymaltose on acquisition of malarial parasitaemia in anaemic Indonesian schoolchildren: a randomized trial.Malaria journal · 2017Trial
- Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: a randomized study.The American journal of clinical nutrition · 2014Trial
- Mechanisms and Therapeutic Potential of Nutritional Immunity.Pathogens (Basel, Switzerland) · 2026Review
- Article
- Integrating and coordinating programs for the management of anemia across the life course.Annals of the New York Academy of Sciences · 2023Article
- Article
- Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.British journal of haematology · 2021Review
- Iron Deficiency Anemia in Children Residing in High and Low-Income Countries: Risk Factors, Prevention, Diagnosis and Therapy.Mediterranean journal of hematology and infectious diseases · 2020Review
- Hemoglobin Levels and the Risk of Malaria in Papua New Guinean Infants: A Nested Cohort Study.The American journal of tropical medicine and hygiene · 2017Article
- Safety and benefits of antenatal oral iron supplementation in low-income countries: a review.British journal of haematology · 2017Review
- Dynamic control of hepatic Plasmodium numbers by hepcidin despite elevated liver iron during iron supplementation.Microbes and infection · 2016Article
- Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline.AIDS research and human retroviruses · 2016Observational
- Chronic inflammation and iron metabolism.The Journal of pediatrics · 2015Article
- Hemoglobinopathic erythrocytes affect the intraerythrocytic multiplication of Plasmodium falciparum in vitro.The Journal of infectious diseases · 2014Article
- Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya.The American journal of clinical nutrition · 2014Article
- The iron fist: malaria and hepcidin.Blood · 2014Article
- Article
- Influence of host iron status on Plasmodium falciparum infection.Frontiers in pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The populations in greatest need of iron supplementation are also those at greatest risk of malaria: pregnant women and young children. Iron supplementation has been shown to increase malaria risk in these groups in numerous studies, although this effect is likely diminished by factors such as host immunity, host iron status, and effective malaria surveillance and control. Conversely, the risk of anemia is increased by malaria infections and preventive measures against malaria decrease anemia prevalence in susceptible populations without iron supplementation. Studies have shown that subjects with malaria experience diminished absorption of orally administered iron, so that as a consequence, iron supplementation may have generally reduced efficacy in malarious populations. A possible mechanistic link between malaria, poor absorption of iron, and anemia is provided by recent research on hepcidin, the human iron control hormone. Our improved understanding of iron metabolism may contribute to the control of malaria and the treatment of anemia. Malaria surveillance and control are necessary components of programs to control iron deficiency and may enhance the efficacy of iron supplementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.