ArticleAnnals of nuclear medicine2012
F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability.
Article in Annals of nuclear medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Trajectories and determinants of echocardiographic myocardial work indices after acute myocardial infarction: a pilot study.Echo research and practice · 2026Article
- Positron emission tomography reveals increased myocardial glucose uptake in a subset of Friedreich ataxia patients.Scientific reports · 2025Article
- Improvement in the estimation of perfusable tissue fraction and myocardial flow reserve in the ischemic myocardial lesions using ECG-gated dynamic myocardial PET withAnnals of nuclear medicine · 2024Article
- Assessment of myocardial viability using a [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Assessment of myocardial viability with [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Relationship between residual viable myocardium and LV remodeling post-MI: Only part of the story.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs.Frontiers in pharmacology · 2016Article
- Advanced tracers in PET imaging of cardiovascular disease.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectives(15)O-water-perfusable tissue fraction (PTF) has been shown to be a potential index for assessing myocardial viability in PET, an alternative to (18)F-fluorodeoxyglucose (FDG). This study aimed to directly compare these two independent methods in assessing myocardial viability in patients with abnormal wall motion.
methodsPET study was performed on 16 patients with previous myocardial infarction, before coronary artery bypass graft operation (CABG). The protocol included a (15)O-carbonmonoxide static, a (15)O-water dynamic and an (18)F-FDG dynamic scan, during the euglycemic hyperinsulinemic clamp. Echocardiography was performed at the time of PET and 5-12 months after the CABG, and the wall motion recovery was evaluated on segmental and global bases. Consistency between PTF and (18)F-FDG was evaluated visually and also in a quantitative manner. Predictive values for the wall motion recovery were also compared between the two approaches.
resultsThe image quality of (18)F-FDG was superior to that of (15)O-water. The qualitative PTF showed significantly smaller defects than (18)F-FDG, and the quantitative PTF showed slightly greater values than (18)F-FDG in the infarcted region. The two methods were, however, consistent visually and also quantitatively. The predictive values of the wall motion recovery were almost equal between the two approaches. The absolute (18)F-FDG uptake was varied in normal segments, and predictive values for the wall motion recovery by the absolute (18)F-FDG was less (accuracy: 80 %) compared with those by the relative (18)F-FDG (accuracy: 87 %) and the quantitative PTF (accuracy: 89 %).
conclusionDespite the small sample size, PTF appears to give consistent results with the (18)F-FDG approach, and might be an alternative viability assessment.
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