ArticleEuropean archives of psychiatry and clinical neuroscience2013
Clinical predictors of seizure threshold in electroconvulsive therapy: a prospective study.
Article in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Investigating the efficacy of Ginkgo biloba on the cognitive function of patients undergoing treatment with electric shock: a double-blind clinical trial.Journal of medicine and life · 2022Trial
- Effectiveness of Emotional Memory Reactivation vs Control Memory Reactivation Before Electroconvulsive Therapy in Adult Patients With Depressive Disorder: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Seizure threshold increases can be predicted by EEG quality in right unilateral ultrabrief ECT.European archives of psychiatry and clinical neuroscience · 2017Trial
- Clinical Outcomes and Treatment Characteristics of Seizure Threshold-Titrated Electroconvulsive Therapy in Depressive Disorder: A 3.5-Year Retrospective Naturalistic Course-Level Study.Journal of clinical medicine · 2026Article
- Ventilation strategies used during anaesthesia for electroconvulsive therapy: scoping review protocol.BMJ open · 2025Article
- Ictal Electroencephalogram Visual Pattern Recognition of Seizure Adequacy During Electroconvulsive Therapy Treatment: A Step-by-Step Approach.The Malaysian journal of medical sciences : MJMS · 2023Article
- Effects of Reflexology on the Pain Intensity among Patients with Depression after Receiving Electroconvulsive Therapy: A Randomized Clinical Trial.Journal of caring sciences · 2021Article
- Factors Predicting Ictal Quality in Bilateral Electroconvulsive Therapy Sessions.Brain sciences · 2021Article
- Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy".Frontiers in psychiatry · 2021Article
- The Efficacy and Safety of Concomitant Psychotropic Medication and Electroconvulsive Therapy (ECT).CNS drugs · 2020Review
- Overlooking the obvious? Influence of electrolyte concentrations on seizure quality parameters in electroconvulsive therapy.European archives of psychiatry and clinical neuroscience · 2020Article
- Initial Seizure Threshold in Brief-Pulse Bilateral Electroconvulsive Therapy in Patients with Schizophrenia or Schizoaffective Disorder.Psychiatry investigation · 2019Article
- Article
- Polymorphism of the brain-derived neurotrophic factor and dynamics of the seizure threshold of electroconvulsive therapy.European archives of psychiatry and clinical neuroscience · 2017Article
- Effects of Psychotropic Drugs on Seizure Threshold during Electroconvulsive Therapy.Psychiatry investigation · 2017Article
- Impact of High Dose Lorazepam on Seizure Threshold in Catatonia: Experience from a Case Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Article
- Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study.European archives of psychiatry and clinical neuroscience · 2015Article
- Effect of anatomical variability on electric field characteristics of electroconvulsive therapy and magnetic seizure therapy: a parametric modeling study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2015Article
- Impact of the anesthetic agents ketamine, etomidate, thiopental, and propofol on seizure parameters and seizure quality in electroconvulsive therapy: a retrospective study.European archives of psychiatry and clinical neuroscience · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the start and during the course of electroconvulsive therapy (ECT), estimation of the seizure threshold (ST) is useful in weighing the expected effectiveness against the risks of side effects. Therefore, this study explores clinical factors predicting initial ST (IST) and levels of ST during the ECT course. This prospective observational study included patients aged ≥18 years receiving ECT without contraindications for dose titration. At the first and every sixth consecutive ECT session, ST level was measured. Using multivariate linear regression and multilevel models, predictors for IST and change in ST levels were examined. A total of 91 patients (mean age, 59.1 ± 15.0 years; 37 % male; 97 % diagnosis of depression) were included. In multivariable analysis, higher age (β = 0.24; P = 0.03) and bifrontotemporal (BL) electrode placement (β = 0.42; P < 0.001) were independent predictors for higher IST, explaining 49 % of its variation. Also, these two variables independently predicted higher ST levels at different time points during the course. Using multilevel models, absence of a previous ECT course(s) predicted a steeper rise in ST during the course (P = 0.03 for the interaction term time*previous ECT). The age-adjusted dose-titration method is somewhat crude, resulting in some measurement error. Concomitant medication use could have influenced ST levels. Increasing age and BL electrode placement predicted higher (I)ST, which should be taken into account when selecting ECT dosage. Previous ECT course(s) may avoid an increase in ST during the course of ECT.
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