ArticleChest2012
Characterization of the upper esophageal sphincter response during cough.
Article in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Correlation Between Peak Upper Esophageal Sphincter and Pharyngeal Pressures in Patients With Dysphagia.Laryngoscope investigative otolaryngology · 2025Article
- Characterization of upper esophageal sphincter pressures relative to vocal acoustics.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Clinical analysis of tubular stapler-assisted nested anastomosis in the prevention of postoperative esophageal cancer complications.Journal of gastrointestinal oncology · 2023Article
- Trends in laparoscopic anti-reflux surgery: a Korea nationwide study.Surgical endoscopy · 2021Article
- Oropharyngeal dysphagia: manifestations and diagnosis.Nature reviews. Gastroenterology & hepatology · 2016Review
- Mechanisms of cough provocation and cough resolution in neonates with bronchopulmonary dysplasia.Pediatric research · 2015Article
- Clinical significance of laryngopharyngeal reflux in patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Article
- Anatomophysiology of the pharyngo-upper esophageal area in light of high-resolution manometry.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Article
- The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes.Cough (London, England) · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVagal reflex initiated by esophageal stimulation and microaspiration can cause chronic cough in patients with gastroesophageal reflux disease (GERD). By raising intraabdominal pressure,cough can, in turn, predispose to GERD. The role of the upper esophageal sphincter (UES)in preventing esophagopharyngeal reflux during coughing is not well known. The aim of this study was to evaluate the UES response during coughing.
methodsWe studied 20 healthy young (10 women; age, 27 ± 5 years) and 15 healthy elderly(nine women; age, 73 ± 4 years) subjects. Hard and soft cough-induced pressure changes in the UES, distal esophagus, lower esophageal sphincter, and stomach were determined simultaneously using high-resolution manometry and concurrent acoustic cough recordings.
resultsResting UES pressure was significantly higher in the young compared with the elderly subjects (42 ± 14 mm Hg vs 24 ± 9 mm Hg; P < .001). Cough induced a UES contractile response in all subjects. Despite lower UES resting pressures in the elderly subjects, the maximum UES pressure during cough was similar between the young and the elderly subjects (hard cough, 230 ± 107 mm Hg vs 278 ± 125 mm Hg, respectively; soft cough, 156 ± 85 mm Hg vs 164 ± 119 mm Hg, respectively; P not significant for both). The UES pressure increase over baseline during cough was significantly higher than that in the esophagus, lower esophageal sphincter, and stomach for both groups ( P < .001).
conclusionsCough induces a rise in UES pressure, and this response is preserved in elderly people. A cough-induced rise in UES pressure is significantly higher than that in the esophagus and stomach,thereby providing a barrier against retrograde entry of gastric contents into the pharynx.
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