Evidence map›Paper›PMID 22797478›Full record

ArticleBMJ case reports2010

A girl with type 1 diabetes and a yellowish appearance.

I C L Kremer Hovinga, E D Stam, M L Mearin, D Mul

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

I C L Kremer HovingaDepartment of Pediatrics, 't Lange Land Hospital, Zoetermeer, The Netherlands. i.c.l.kremer-hovinga@lumc.nl
E D Stam
M L Mearin
D Mul
Leiden University Medical Center · NLLange Land Ziekenhuis · NLLoyola University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes mellitus in children has been associated with other autoimmune diseases, especially coeliac disease and autoimmune thyroiditis. This association may be the result of a common pathogenic background. We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children. Thyroiditis-associated and diabetes-associated autoantibodies were also present. Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes. This finding implies that similar pathogenic pathways may be involved in different autoimmune diseases including type 1 diabetes and autoimmune hepatitis. The patient was successfully treated with prednisolone and azathioprine. Autoimmune hepatitis can be a serious co-occurring disease in patients with type 1 diabetes.

Indexed as

Anti-Inflammatory AgentsAutoantibodiesAzathioprineChildDiabetes Mellitus, Type 1Drug Therapy, CombinationFemaleGenetic Carrier ScreeningHepatitis, AutoimmuneHLA-DRB1 ChainsHumansImmunosuppressive AgentsInsulinJaundicePrednisoloneThyroiditis, AutoimmuneAnti-Inflammatory AgentsAutoantibodiesAzathioprineHLA-DRB1 ChainsImmunosuppressive AgentsInsulinPrednisolone

Identifiers

PMID22797478
PMCPMC3029158
OpenAlexW2059442861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.