ArticleThe Plant cell2012
Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 223 citations in OpenAlex.
- Arabidopsis GOLDEN2-LIKE transcription factors interact with ABA-INSENSITIVE 4 to modulate cotyledon greening in light-exposed etiolated seedlings.Journal of experimental botany · 2026Article
- Trp521 oxidation affects FtsH2 stability and its role in PSII repair.The New phytologist · 2026Article
- EXECUTER-mediated singlet oxygen signaling in plants: Mechanisms, evolution, and functional diversification.Plant communications · 2026Review
- Article
- Biogenic retrograde signaling via GUN1 ensures thermotolerant chloroplast biogenesis during seedling establishment in Arabidopsis thaliana.Journal of integrative plant biology · 2026Article
- Simultaneous defects in chloroplast development and division cause leaf variegation in Arabidopsis.Plant communications · 2026Article
- Article
- Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling.Plant, cell & environment · 2025Review
- A fungal effector promotes infection via stabilizing a negative regulatory factor of chloroplast immunity.Nature communications · 2025Article
- EXECUTER1 and singlet oxygen signaling: A reassessment of nuclear activity.The Plant cell · 2024Article
- Effect of Chloroplast ATP Synthase on Reactive Oxygen Species Metabolism in Cotton.International journal of molecular sciences · 2024Article
- Does the polyubiquitination pathway operate inside intact chloroplasts to remove proteins?The Plant cell · 2024Article
- A molecular atlas of plastid and mitochondrial proteins reveals organellar remodeling during plant evolutionary transitions from algae to angiosperms.PLoS biology · 2024Article
- Alternaria TeA toxin activates a chloroplast retrograde signaling pathway to facilitate JA-dependent pathogenicity.Plant communications · 2024Article
- Singlet Oxygen Detection by Chemiluminescence Probes in Living Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Plant competition cues activate a singlet oxygen signaling pathway inFrontiers in plant science · 2024Article
- Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots.Nature plants · 2023Article
- CaPlant molecular biology · 2023Article
- Comparative transcriptome analysis of Zea mays upon mechanical wounding.Molecular biology reports · 2023Article
- Singlet oxygen-induced signalling depends on the metabolic status of the Chlamydomonas reinhardtii cell.Communications biology · 2023Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Enhanced levels of singlet oxygen ((1)O(2)) in chloroplasts trigger programmed cell death. The impact of (1)O(2) production in chloroplasts was monitored first in the conditional fluorescent (flu) mutant of Arabidopsis thaliana that accumulates (1)O(2) upon a dark/light shift. The onset of (1)O(2) production is rapidly followed by a loss of chloroplast integrity that precedes the rupture of the central vacuole and the final collapse of the cell. Inactivation of the two plastid proteins EXECUTER (EX1) and EX2 in the flu mutant abrogates these responses, indicating that disintegration of chloroplasts is due to EX-dependent signaling rather than (1)O(2) directly. In flu seedlings, (1)O(2)-mediated cell death signaling operates as a default pathway that results in seedlings committing suicide. By contrast, EX-dependent signaling in the wild type induces the formation of microlesions without decreasing the viability of seedlings. (1)O(2)-mediated and EX-dependent loss of plastid integrity and cell death in these plants occurs only in cells containing fully developed chloroplasts. Our findings support an as yet unreported signaling role of (1)O(2) in the wild type exposed to mild light stress that invokes photoinhibition of photosystem II without causing photooxidative damage of the plant.
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