ReviewChest2012
Biomarkers of sleep apnea.
Review in Chest, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04093102 (Role of Biomarkers to Screen for Obstructive Sleep Apnea), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Biomarkers to Screen for Obstructive Sleep Apnea
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of continuous positive airway pressure therapy on inflammatory markers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Is video demonstration for type III sleep studies performance worse than technical face-to-face teaching?Sleep & breathing = Schlaf & Atmung · 2024Trial
- Obstructive Sleep Apnea Endophenotypes.Sleep science (Sao Paulo, Brazil) · 2025Review
- Integrative analysis of candidate MicroRNAs and gene targets for OSA management using in silico and in-vitro approach.Biotechnology notes (Amsterdam, Netherlands) · 2025Article
- Early screening of sleep disordered breathing in hospitalized stroke patients high-resolution pulse oximetry as prognostic and early intervention tools in patients with acute stroke and sleep apnea (HOPES TRIAL).Sleep & breathing = Schlaf & Atmung · 2024Article
- A narrative review on obstructive sleep apnoea syndrome in paediatric population.Frontiers in neurology · 2024Review
- Urinary Epinephrine Sulfate Can Predict Cardiovascular Risk in Moderate-to-Severe OSA: A Metabolomics-Based Study.Nature and science of sleep · 2024Article
- Obstructive sleep apnea alters microRNA levels: Effects of continuous positive airway pressure.Medical research archives · 2024Article
- The impact of obstructive sleep apnea on exercise capacity in a cardiac rehabilitation program.Sleep & breathing = Schlaf & Atmung · 2023Article
- Emerging role of metabolomics for biomarker discovery in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2023Review
- Advanced Proteomics and Cluster Analysis for Identifying Novel Obstructive Sleep Apnea Subtypes before and after Continuous Positive Airway Pressure Therapy.Annals of the American Thoracic Society · 2023Article
- Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea.Biomolecules · 2023Article
- Surface Active Salivary Metabolites Indicate Oxidative Stress and Inflammation in Obstructive Sleep Apnea.Allergy, asthma & immunology research · 2023Article
- The role of neuromuscular function in sleep apnea pathogenesis and management: A consensus of experts.Frontiers in sleep · 2023Review
- Changes in Left Heart Geometry, Function, and Blood Serum Biomarkers in Patients with Obstructive Sleep Apnea after Treatment with Continuous Positive Airway Pressure.Medicina (Kaunas, Lithuania) · 2022Article
- Towards Validating the Effectiveness of Obstructive Sleep Apnea Classification from Electronic Health Records Using Machine Learning.Healthcare (Basel, Switzerland) · 2021Article
- Urine 5-Eicosatetraenoic Acids as Diagnostic Markers for Obstructive Sleep Apnea.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Machine and Deep Learning in Molecular and Genetic Aspects of Sleep Research.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Endotypes and phenotypes in obstructive sleep apnea.Current opinion in pulmonary medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is a condition of repetitive upper airway collapse, which occurs during sleep. Recent literature has emphasized the role of OSA in contributing to glucose intolerance, dyslipidemia, and hypertension. OSA is associated with the development of cardiovascular disease, although definitive data are sparse with regard to the prevention of cardiovascular disease and CPAP therapy. CPAP provides effective treatment for OSA, but patient adherence remains challenging. Aside from daytime symptom improvement, it is difficult to monitor the adequacy of treatment response. Thus, the search for a biomarker becomes critical. The discovery of an ideal biomarker for OSA has the potential to provide information related to diagnosis, severity, prognosis, and response to treatment. In addition, because large-scale randomized controlled trials are both ethically and logistically challenging in assessing hard cardiovascular outcomes, certain biomarkers may be reasonable surrogate outcome measures. This article reviews the literature related to potential biomarkers of OSA with the recognition that an ideal biomarker does not exist at this time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.