ArticleNature nanotechnology2012
Piezoelectric nanoribbons for monitoring cellular deformations.
Article in Nature nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 186 citations in OpenAlex.
- Ultrasound-mediated piezoelectricity enhancement in bioresorbable polymers.Bioactive materials · 2026Article
- Toward continuous monitoring systems: emerging trends of on-chip sensors in organ-on-a-chip.Microsystems & nanoengineering · 2026Review
- Adhesive-Electrocoupling Hydrogels for Tissue Regeneration: Design, Mechanisms, and Perspectives.Research (Washington, D.C.) · 2026Review
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Fully biodegradable hierarchically designed high-performance nanocellulose piezo-arrays.Science advances · 2025Article
- Piezoelectricity of BiNanomaterials (Basel, Switzerland) · 2023Article
- Stretchable polymer composites with ultrahigh piezoelectric performance.National science review · 2023Article
- Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications.Science advances · 2023Article
- Green Fabrication of Freestanding Piezoceramic Films for Energy Harvesting and Virus Detection.Nano-micro letters · 2023Article
- Nib-Assisted Coaxial Electrohydrodynamic Jet Printing for Nanowires Deposition.Nanomaterials (Basel, Switzerland) · 2023Article
- Computational Study of Drop-on-Demand Coaxial Electrohydrodynamic Jet and Printing Microdroplets.Micromachines · 2023Article
- Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Numerical modeling and analysis of coaxial electrohydrodynamic jet printing.Scientific reports · 2022Article
- On the Coupling between Mechanical Properties and Electrostatics in Biological Membranes.Membranes · 2021Review
- Nanotechnology Facilitated Cultured Neuronal Network and Its Applications.International journal of molecular sciences · 2021Review
- Fundamental Definitions for Axially-Strained Piezo-Semiconductive Nanostructures.Micromachines · 2020Article
- Review
- An ill-posed boundary condition was inadvertently implemented when deriving the expression to characterize deformation of neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reply to Farrell: Experimental evidence is the ultimate judge for model assumptions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods for probing mechanical responses of mammalian cells to electrical excitations can improve our understanding of cellular physiology and function. The electrical response of neuronal cells to applied voltages has been studied in detail, but less is known about their mechanical response to electrical excitations. Studies using atomic force microscopes (AFMs) have shown that mammalian cells exhibit voltage-induced mechanical deflections at nanometre scales, but AFM measurements can be invasive and difficult to multiplex. Here we show that mechanical deformations of neuronal cells in response to electrical excitations can be measured using piezoelectric PbZr(x)Ti(1-x)O(3) (PZT) nanoribbons, and we find that cells deflect by 1 nm when 120 mV is applied to the cell membrane. The measured cellular forces agree with a theoretical model in which depolarization caused by an applied voltage induces a change in membrane tension, which results in the cell altering its radius so that the pressure remains constant across the membrane. We also transfer arrays of PZT nanoribbons onto a silicone elastomer and measure mechanical deformations on a cow lung that mimics respiration. The PZT nanoribbons offer a minimally invasive and scalable platform for electromechanical biosensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.