ArticleBehavioural brain research2012
Tongue force and tongue motility are differently affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Systematic Review of Oropharyngeal Dysphagia Models in Rodents.International journal of environmental research and public health · 2021Pooled it
- Differential associations between tongue pressure and handgrip strength with MDS-UPDRS part III motor symptoms in Parkinson's disease.Frontiers in neurology · 2026Observational
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Research advances in dysphagia animal models.Animal models and experimental medicine · 2025Review
- Corticobulbar activity in healthy humans and Parkinson's disease: a study protocol for a novel biomarker of motivational arousal.Frontiers in psychology · 2025Article
- rTMS improves dysphagia by inhibiting NLRP3 inflammasome activation and caspase-1 dependent pyroptosis in PD mice.NPJ Parkinson's disease · 2024Article
- Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence.Current neuropharmacology · 2023Article
- Assays of tongue force, timing, and dynamics in rat and mouse models.Brain research bulletin · 2022Review
- Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson's disease.The journal of physiological sciences : JPS · 2020Article
- Autonomic dysfunction in Parkinson disease and animal models.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Disruption of Cortical Dopaminergic Modulation Impairs Preparatory Activity and Delays Licking Initiation.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration.Neuroscience letters · 2019Article
- A Dual-Mode Magnetic-Acoustic System for Monitoring Fluid Intake Behavior in Animals.IEEE transactions on bio-medical engineering · 2017Article
- Animal Models for Dysphagia Studies: What Have We Learnt So Far.Dysphagia · 2017Review
- Modification of spectral features by nonhuman primates.The Behavioral and brain sciences · 2014Article
- Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats.Psychopharmacology · 2014Article
- Modulation dynamics in the orofacial sensorimotor cortex during motor skill acquisition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease.Behavioural brain research · 2013Article
- Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion.Behavioural brain research · 2013Article
- Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In addition to its cardinal symptoms of bradykinesia, muscle rigidity, resting tremor and postural disturbances, Parkinson's disease (PD) also affects orolingual motor function. Orolingual motor deficits can contribute to dysphagia, which increases morbidity and mortality in this population. Previous preclinical studies describing orolingual motor deficits in animal models of PD have focused on unilateral nigrostriatal dopamine (DA) depletion. In this study we compared the effects of unilateral vs bilateral 6-hydroxydopamine (6-OHDA)-induced DA depletion in rats trained to lick water from an isometric force-sensing disc. Rats received either unilateral or bilateral 6-OHDA into the medial forebrain bundle and were tested for four weeks post-lesion. Dependent variables included task engagement (the number of licks per session), tongue force (mean and maximum), and tongue motility (the number of licks per second). While both lesion groups exhibited decreased tongue force output, tongue motility deficits were present in only the group that received unilateral nigrostriatal DA depletion. Task engagement was not significantly diminished by 6-OHDA. Analysis of striatal DA tissue content revealed that DA depletion was ∼97% in the unilateral group and ∼90% in the bilateral group. These results suggest that while nigrostriatal DA depletion affects tongue force output, deficits in tongue motility may instead result from a functional imbalance in neural pathways affecting this midline structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.